A Novel H-Phosphonamidate method for the Synthesis of d4T 5′-Selenophosphoramidates

Shan Shan Gong; Guo Dong Liu; Xing Jian Li; Qi Sun

doi:10.4028/www.scientific.net/AMR.830.147

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830A Novel H-Phosphonamidate method for the Synthesis...

A Novel H-Phosphonamidate method for the Synthesis of d4T 5′-Selenophosphoramidates

Abstract:

A series of d4T 5′-selenophosphoramidates were prepared in good yields from d4T 5′-H-phosphonamidates. H-Phosphonamidates were silylated with TMSCl, and then oxidized with selenium in the presence of DBU to afford d4T 5′-selenophosphoramidates. Due to the lowered electron density on the P atom of H-phosphonamidates, these intermediates were less prone to be oxidized than their P–O counterparts.

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Periodical:

Advanced Materials Research (Volume 830)

Pages:

147-150

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.147

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Online since:

October 2013

Authors:

Shan Shan Gong, Guo Dong Liu, Xing Jian Li, Qi Sun*

Keywords:

Antiviral Nucleoside, d4T, H-Phosphonamidate, Prodrug, Selenophosphoramidate

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