Synthesis of Carboxybenzyl-Protected 2′-Deoxynucleoside 5′-Phosphoromorpholidates

Shan Shan Gong; Guo Dong Liu; Qi Sun

doi:10.4028/www.scientific.net/AMR.830.139

Paper Titles

Butanol Production Using Carbohydrate-Enriched Chlorella vulgaris as Feedstock
p.122

Study on Concentrate Tannin from Gallnut Extract by Membrane Integrated Method
p.126

Investigation of Y_1-xCa_xBaCo₂O_5+δ Cathodes for Intermediate-Temperature Solid Oxide Fuel Cells
p.130

A Novel Strategy for the Synthesis of Azetidine
p.135

Synthesis of Carboxybenzyl-Protected 2′-Deoxynucleoside 5′-Phosphoromorpholidates
p.139

An Improved H-Phosphonate Method for the Preparation of α-L-Rhamnosy-1-Phosphoramidates of Amino Acid Methyl Esters
p.143

A Novel H-Phosphonamidate method for the Synthesis of d4T 5′-Selenophosphoramidates
p.147

A Practical Synthesis of 3β-Amino-5-Cholestene
p.151

Microwave-Assisted FeCl₃·6H₂O-Catalyzed Regioselective Deprotection of Pyranose Anomeric O-Acetyl Group
p.155

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830Synthesis of Carboxybenzyl-Protected...

Synthesis of Carboxybenzyl-Protected 2′-Deoxynucleoside 5′-Phosphoromorpholidates

Abstract:

Four deoxynucleoside 5′-phosphoromorpholidates were prepared from carboxybenzyl-protected 2′-deoxyribonucleosides. The synthetic route involved three consecutive steps including phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling reactions.