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A Practical Synthesis of 3β-Amino-5-Cholestene

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Abstract:

Derivatives of 3β-amino-5-cholestene are of substantial interest to chemical biologists and have potential medicinal value. A novel and practical method for the preparation of 3β-amino-5-cholestene from inexpensive cholesterol has been developed. To synthesize the epicholesterol intermediate, the KO2 method reported by Corey and coworkers was applied in this synthetic route and solved the problems of the known synthetic route involving epicholesterol intermediate.

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Periodical:

Advanced Materials Research (Volume 830)

Pages:

151-154

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.151

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Online since:

October 2013

Authors:

Yue Hai You, Shan Shan Gong, Qi Sun*

Keywords:

18-Crown-6, 3β-Amino-5-cholestene, Cholesterol, Epicholesterol, KO2

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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