A Novel Synthesis of Protected Nucleoside 5'-Phosphoromorpholidates

Hai Xin Ding; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.830.226

Paper Titles

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Selective Synthesis of 2-Substituted and 1,2-Disubstituted Benzimidazoles
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One-Pot Synthesis of P¹,P²-Diaciclovir-5'-Diphosphate from Aciclovir 5'-H-Phosphonate
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830A Novel Synthesis of Protected Nucleoside...

A Novel Synthesis of Protected Nucleoside 5'-Phosphoromorpholidates

Abstract:

A general synthesis of nucleoside 5'-phosphoromorpholidates from carboxybenzyl-protected nucleosides has been developed. Phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling generated the phosphomorpholidate products in high yields.

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Periodical:

Advanced Materials Research (Volume 830)

Pages:

226-229

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.226

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Online since:

October 2013

Authors:

Hai Xin Ding, Shan Shan Gong*, Qi Sun

Keywords:

Carboxybenzyl, Nucleoside 5'-Phosphoromorpholidate, Phosphoramidate, Phosphoramidite

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