Synthesis of AZT 5'-Selenophosphoramidates via AZT 5'-H-Phosphonamidates

Xing Jian Li; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.830.238

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830Synthesis of AZT 5'-Selenophosphoramidates via AZT...

Synthesis of AZT 5'-Selenophosphoramidates via AZT 5'-H-Phosphonamidates

Abstract:

A novel and efficient method for the preparation of AZT 5'-selenophosphoramidates has been developed. Silylation of AZT 5'-H-phosphonamidates, followed by oxidative coupling and hydrolysis afforded 5'-selenophosphoramidates of AZT in good yields.

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Periodical:

Advanced Materials Research (Volume 830)

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238-241

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.238

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Online since:

October 2013

Authors:

Xing Jian Li, Shan Shan Gong*, Qi Sun

Keywords:

Antiviral Nucleoside, AZT, H-Posphonamidate, Prodrug, Selenophosphoramidate

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