Ultrasonic-Assisted Deprotection of tert-Butyldimethylsilyl Ethers with Bromotrichloromethane in Methanol

Jian Sun; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.830.230

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Ultrasonic-Assisted Deprotection of tert-Butyldimethylsilyl Ethers with Bromotrichloromethane in Methanol
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830Ultrasonic-Assisted Deprotection of...

Ultrasonic-Assisted Deprotection of tert-Butyldimethylsilyl Ethers with Bromotrichloromethane in Methanol

Abstract:

Treatment of tert-butyldimethylsilyl (TBDMS) ethers of nucleosides with bromo-trichloromethane (CBrCl₃) in methanol under ultrasonic conditions provides a mild and efficient method for desilylation. The experimental results showed that the employment of ultrasonic could notably improve the reaction efficiency compared with thermal heating condition.

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Periodical:

Advanced Materials Research (Volume 830)

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230-233

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.230

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Online since:

October 2013

Authors:

Jian Sun, Shan Shan Gong*, Qi Sun

Keywords:

Bromotrichloromethane, Desilylation, Nucleoside, Tert-Butyldimethylsilyl Ether, Ultrasonic

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