A Novel Synthesis of Acyclovir Polyphosphates via Acyclovir Phosphoropiperidate Intermediate

Xing Jian Li; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.908.203

Paper Titles

Simultaneous Absorption of SO₂ and NO Using Sodium Chlorate/Urea Absorbent in a Rotating Packed Bed
p.187

The Conjecture of Obtain C₄H₆O⁺ Fragments by Cyclicketone Ion Excited State
p.191

Comparative Study on the Effect of Preparation of TiO₂ and the Photocatalytic Degradation of Phenol Based on the Biological Template
p.195

Synthesis of Inosine Polyphosphates from Inosine 5’-Phosphate
p.199

A Novel Synthesis of Acyclovir Polyphosphates via Acyclovir Phosphoropiperidate Intermediate
p.203

Practical Synthesis of β,γ-Bridging Oxygen-Modified Stavudine 5’-Triphosphates
p.207

Efficient Synthesis of d4T Diphosphate and d4T Triphosphate
p.211

Solid-Phase Synthesis of Pyrrole-Imidazole Polyamides by Resin
p.215

Research on Biological Materials with Oxazinone Derivatives Induce Apoptosis in HT-29 Cells
p.220

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 908A Novel Synthesis of Acyclovir Polyphosphates via...

A Novel Synthesis of Acyclovir Polyphosphates via Acyclovir Phosphoropiperidate Intermediate

Abstract:

A novel and efficient method for the preparation of acyclovir diphosphate and triphosphate has been developed. Phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling with piperidine yielded acyclovir phosphoropiperidate benzyl ester intermediate in excellent yield. Acyclovir polyphosphates were synthesized in good yields by using the phosphoropiperidate/DCI system.

You might also be interested in these eBooks

Materials Science, Environment Protection and Applied Research

View Preview

Info:

Periodical:

Advanced Materials Research (Volume 908)

Pages:

203-206

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.908.203

Citation:

Cite this paper

Online since:

March 2014

Authors:

Xing Jian Li, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Acyclic Nucleoside, Phosphoropiperidate, Pyrophosphate

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] D.M. Richards, A.A. Carmine, E.N. Brogden, R.C. Heel, T.M. Speight, and G.S. Avery, Drugs, Vol. 26 (1983), p.378.

DOI: 10.2165/00003495-198326050-00002

Google Scholar

[2] H. Schaffer, V. Robert, S. Bittner, S. Gurwara, J. Med. Chem. Vol. 14 (1971), p.367.

Google Scholar

[3] B. Öberg, Antiviral Res. Vol. 71 (2006), p.90.

Google Scholar

[4] M.M. Vaghefi, in: Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, edtied by M.M. Vaghefi Taylor & Francis: Boca Raton, FL (2005), in press.

DOI: 10.1201/9781420027600.ch4

Google Scholar

[5] K. Burgess, D. Cook, Chem. Rev. Vol. 100 (2000), p. (2047).

Google Scholar

[6] L. Weinschenk, C. Meier, in: Chemical Synthesis of Nucleoside Analogues, edited by P. Merino, chapter, 5, John Wiley & Sons, Hoboken, NJ (2013).

Google Scholar

[7] J. Ludwig, Acta Biochim. Biophys. Hung. Vol. 16 (1981), p.131.

Google Scholar

[8] J. Ludwig, F. Eckstein, J. Org. Chem. Vol. 54 (1989), p.631.

Google Scholar

[9] F. Eckstein, W. Bruns, A. Parmeggiani, Biochemistry, Vol. 14 (1975), p.5225.

Google Scholar

[10] V.S. Bogachev, Russ. J. Bioorg. Chem. Vol. 22 (1996), p.599.

Google Scholar

[11] Q. Sun, S. -S. Gong, J. Sun, S. Liu, Q. Xiao, S. -Z. Pu, J. Org. Chem. Vol. 78 (2013), p.8417.

Google Scholar