Efficient Synthesis of d4T Diphosphate and d4T Triphosphate

Zhen Biao Xie; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.908.211

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 908Efficient Synthesis of d4T Diphosphate and d4T...

Efficient Synthesis of d4T Diphosphate and d4T Triphosphate

Abstract:

The diphosphate and triphosphate of an antiviral 2’,3’-dideoxynucleoside, d4T, were synthesized via a P(V)–N activation method. The key d4T phosphoropiperidate intermediate was obtained by a redox condensation method based on 2,2’-dithiodipyridine/triphenylphosphine system. The reaction of the phosphoropiperidate with phosphate and pyrophosphate in the presence of acidic 4,5-dicyanoimidazole activator afforded the desired d4T diphosphate and triphosphate in high isolated yields.

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Periodical:

Advanced Materials Research (Volume 908)

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211-214

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.908.211

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Online since:

March 2014

Authors:

Zhen Biao Xie, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, d4T, Diphosphate, Phosphoropiperidate, Triphosphate

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