Research on Biological Materials with Oxazinone Derivatives Induce Apoptosis in HT-29 Cells

Yan Ling Wu; Li Wen Shen; Yan Ping Ding; Chuan He Wei; Yoshimasa Tanaka; Wen Zhang

doi:10.4028/www.scientific.net/AMR.908.220

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Research on Biological Materials with Oxazinone Derivatives Induce Apoptosis in HT-29 Cells
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 908Research on Biological Materials with Oxazinone...

Research on Biological Materials with Oxazinone Derivatives Induce Apoptosis in HT-29 Cells

Abstract:

Objective: To monitor the induction of apoptosis in HT-29 cells by three compounds of oxazinone derivatives (A-C) with similar structures and research the mechanism of those oxazinone derivatives in induction of apoptosis in HT-29 cells. Methods: HT-29 cells were used for the determination of cytotoxicity elicited by oxazinone compounds. Cytotoxic effects of these compounds in HT-29 cells are monitored by a Real-Time Cell Analyser system. Results: All the oxazinone derivatives exhibited growth inhibition in HT-29 cells in a concentration-dependent manner. Conclusion: All the three compounds of oxazinone derivatives (A-C) could exhibit growth inhibition in HT-29 cells in a dose-dependent manner.

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Periodical:

Advanced Materials Research (Volume 908)

Pages:

220-223

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.908.220

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Online since:

March 2014

Authors:

Yan Ling Wu*, Li Wen Shen, Yan Ping Ding, Chuan He Wei, Yoshimasa Tanaka, Wen Zhang

Keywords:

Apoptosis, HT-29 Cells, Induction, Oxazinone Derivatives, Real-Time Cell Analyser System

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