Practical Synthesis of β,γ-Bridging Oxygen-Modified Stavudine 5’-Triphosphates

Yue Hai You; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.908.207

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 908Practical Synthesis of β,γ-Bridging...

Practical Synthesis of β,γ-Bridging Oxygen-Modified Stavudine 5’-Triphosphates

Abstract:

As non-hydrolyzable analogs of stavudine 5’-triphosphate, β,γ-bridging oxygen-modified stavudine 5’-triphosphates (β,γ-CX₂-NTPs, X = H, F, and Cl) possess potential medicinal value in the treatment of viral infections and are of substantial interest to both synthetic and medicinal chemists. Three β,γ-bridging oxygen-modified stavudine 5’-triphosphates were synthesized from stavudine 5’-phosphoropiperidate with 4,5-dicyanoimidazole (DCI) as the activator.

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Periodical:

Advanced Materials Research (Volume 908)

Pages:

207-210

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.908.207

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Online since:

March 2014

Authors:

Yue Hai You, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Diphosphonate, Phosphoropiperidate, Reverse Transcriptase, Stavudine

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