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Study on Biomaterials of Anti-Gastric Trametenolic Acid B Semi-Synthetic Derivatives

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Abstract:

Discovery of bioactive ingredients from plants and fungi is always the hot spots in medicinal chemistry. The trametenolic acid B was a bioactive lanostane-type triterpenoid in Trametes lactinea (Berk.) Pat. In this work, four semi-synthetic derivatives were synthesized, characterized and evaluated the anti-gastric cancer activities against HGC-27 cells with the aim of obtaining better anti-tumor agents. The compounds 2a and 3b possessed good anti-proliferative effects under normal physiological conditions, and their anti-cancer effects increased as the pH decrease to 5.5 with the IC50 of 17.55 and 10.63 μM, respectively. These compounds might be further developed as anti-gastric cancer drugs.

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Periodical:

Advanced Materials Research (Volume 918)

Pages:

32-35

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.918.32

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Online since:

April 2014

Authors:

Xi Ming Yan, Ming Ruo Ding, Ming Guo Liu*, Jun Zhi Wang, Nian Yu Huang

Keywords:

Anti-Gastric Cancer Activity, Semi-Synthesis, Trametenolic Acid B, Triterpenoid

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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