Synthesis of Straight Rod-Shaped Mesoporous Silica Templated with Polyvinylpyrrolidone and P123 for Controlled Ibuprofen Release

Jin Yu Zhang; Bin Jiang; Guo Wei Zhou

doi:10.4028/www.scientific.net/AMR.918.7

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Synthesis of Straight Rod-Shaped Mesoporous Silica Templated with Polyvinylpyrrolidone and P123 for Controlled Ibuprofen Release
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 918Synthesis of Straight Rod-Shaped Mesoporous Silica...

Synthesis of Straight Rod-Shaped Mesoporous Silica Templated with Polyvinylpyrrolidone and P123 for Controlled Ibuprofen Release

Abstract:

Straight rod-shaped mesoporous silica materials (SRMS) were successfully prepared using polyvinylpyrrolidone and triblock copolymer as dual template, which would be further functionalized with (3-aminopropyl) triethoxysilane. SRMS and functionalized SRMS (NH-SRMS) were characterized by means of small-angle X-ray powder diffraction, field emission scanning electron microscopy, transmission electron microscopy, N₂ adsorptiondesorption. The results indicated that SRMS was straight rod-shaped mesoporous silica with a hexagonal symmetry structure (p6mm) and the structure did not change after functionalization. A comparative study of the loading and release of ibuprofen on the carriers of SRMS and NH-SRMS were carried out in phosphate buffered saline. NH-SRMS exhibited a lower release rate than SRMS, suggesting that NH-SRMS was a promising carrier for achieving prolonged drug release.

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Periodical:

Advanced Materials Research (Volume 918)

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7-11

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.918.7

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Online since:

April 2014

Authors:

Jin Yu Zhang, Bin Jiang, Guo Wei Zhou*

Keywords:

Controlled Release, Functionalization, Ibuprofen, Polyvinylpyrrolidone, Straight Rod-Shaped Mesoporous Silica

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