Towards Enhanced Bioactivity: Calcium Ion-Doped Polypyrrole

Abstract:

Based on the unique redox property of electrically conductive polymers, Ca²⁺ was incorporated into polypyrrole (PPy) film that previously doped with polyelectrolyte heparin. Then the apatite-forming ability of the Ca²⁺-doped PPy was examined by a biomimetic method using stimulated body fluid (SBF), which has ion concentration nearly equal to those of human blood plasma. It was found that the Ca²⁺-doped PPy successfully formed bonelike apatite deposition on its surface after soaking in SBF for only 3 days, whereas the similar apatite deposition was formed on Ca²⁺-free PPy after soaking in SBF for 7 days. These indicated that the entrapment of Ca²⁺ into PPy could accelerate the formation of apatite deposition and the Ca²⁺-doped PPy was possessed of enhanced bioactivity. It is expected that the Ca²⁺-doped PPy would be a useful bioactive coating material of metallic medical devices or tissue engineering scaffolds to promote the bone tissue regeneration.

• Periodical: Advanced Materials Research (Volumes 941-944)
• Pages: 1168-1173
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.941-944.1168
• Online since: June 2014
• Authors: Yuan He, Ling Feng Dai, Shi Hui Wang, Ya Nan Sun, Wei Shi, Dong Tao Ge*
• Keywords: Apatite, Bioactivity, Calcium Ion, Polypyrrole (Ppy), Simulated Body Fluid (SBF)

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