Microfluidic Chips with Micro-Pillar Array for Cell Capture

Abstract:

Microfluidic chips with micro-pillar array to capture cancer cells in a small volume were designed and fabricated in this paper. The structure includes two parts. This chip has a glass slide bonded to a silicon structure, and both of them contain twelve micro-channels with patterned chevrons or U-triangle-bones, micro-pillar array is completed on silicon wafers using wet chemical etching method on the substrate. To monitor cell capture tendency of the structure, the rows of capture structure were modeled using the finite element method (COMSOL Multiphysics). The results show that this structure can decrease the impact force to half or even less, the fluid can go through the micro-pillar array equably and the subjects in the flow can be sizing by the structure.

• Periodical: Advanced Materials Research (Volumes 941-944)
• Pages: 2149-2153
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.941-944.2149
• Online since: June 2014
• Authors: Tao Lai*, Guang Long Wang, Feng Qi Gao
• Keywords: Design, Fabrication, Microfluidic Chip, Micro-Pillar Array, Silicon-Glass

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