Numerical Simulation and Experimental Validation of Bound Solute Dialysis in Artificial Liver Support Systems

Ying Ying Pei; Yang Xu; Yi Ze Sun; Da Yong Gao; Wei Ping Ding

doi:10.4028/www.scientific.net/AMR.971-973.107

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 971-973Numerical Simulation and Experimental Validation...

Numerical Simulation and Experimental Validation of Bound Solute Dialysis in Artificial Liver Support Systems

Abstract:

Bound solute dialysis in artificial liver support systems is one of approaches to remove protein-bound toxins from patients with liver disease. In this study, a theoretical mass transfer model for bound solute dialysis considering detailed local ultrafiltration was presented. Then, the numerical simulation was performed and the theoretical results were compared with the experimental data in two dialysis modes under various operating conditions, open-loop dialysis mode (OLM) and closed-loop dialysis mode (CLM).Our results show that the theoretical results agree well with the experimental data. The theoretical model presented here can be used to accurately predict the clearance of albumin-bound toxins and optimize the treatment strategy for clinical application.

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Periodical:

Advanced Materials Research (Volumes 971-973)

Pages:

107-110

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.971-973.107

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Online since:

June 2014

Authors:

Ying Ying Pei*, Yang Xu, Yi Ze Sun, Da Yong Gao, Wei Ping Ding

Keywords:

Artificial Liver Support System, Dialysis, Hollow Fiber Membrane, Toxin, Ultrafiltration

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