Advanced Materials for Gene Delivery

Abstract:

Gene therapy is a widespread and promising treatment of many diseases resulting from genetic disorders, infections and cancer. The feasibility of the gene therapy is mainly depends on the development of appropriate method and suitable vectors. For an efficient gene delivery, it is very important to use a carrier that is easy to produce, stable, non-oncogenic and non-immunogenic. Currently most of the vectors actually suffer from many problems. Therefore, the ideal gene therapy delivery system should be developed that can be easily used for highly efficient delivery and able to maintain long-term gene expression, and can be applicable to basic research as well as clinical settings. This article provides a brief over view on the concept and aim of gene delivery, the different gene delivery systems and use of different materials as a carrier in the area of gene therapy.

• Periodical: Advanced Materials Research (Volume 995)
• Pages: 29-47
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.995.29
• Online since: July 2014
• Authors: Mohammad A. Jafar Mazumder*, Md. Hasan Zahir, Sharif F. Zaman
• Keywords: Cationic Polymers, Cytotoxicity, DNA Plasmid, Gene Delivery, Lipid, Polymer Therapeutics, Transfection

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