Synthesis and Crystal Structure of 1-(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Wei Li; Qiang Xiao; Ru Chun Yang

doi:10.4028/www.scientific.net/AMR.997.196

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 997Synthesis and Crystal Structure of...

Synthesis and Crystal Structure of 1-(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Abstract:

The title compound, 1-(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione , C₉H₁₀FIN₂O₅, as potential drugs for anti-tumor, anti-viral have been synthesized and characterized by NMR spectra. Meanwhile, the crystal of 2b was obtained and determined by X-ray single-crystal diffraction. Crystal data: monoclinic system, space group P2(1), a = 9.0832(11) Ǻ, b = 5.4332(7) Ǻ, c = 12.2464(15) Ǻ, β = 107.809(4)°, V = 575.41(12) Ǻ³, Z = 2, F(000) = 360, D_x = 2.148 Mg m^-3, μ = 2.813 mm^-1, R = 0.014 and wR = 0.056 for 1988 independent reflections (R_int = 0.0209) and 1932 observed ones (I > 2σ (I)).

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Advanced Materials Research (Volume 997)

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196-199

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.997.196

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Online since:

August 2014

Authors:

Wei Li*, Qiang Xiao, Ru Chun Yang

Keywords:

Crystal Structure, Synthesis, X-Ray Diffraction (XRD)

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