An Improved Total Synthesis of 5'-Deoxytoyocamycin

Zhi Zhong Ruan; Zi Wen Gong; Qiang Xiao; Ru Chun Yang

doi:10.4028/www.scientific.net/AMR.997.200

Paper Titles

Influence of Synthesis Parameters on the Formation of SAPO-5 from Metakaolin
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Synthesis of 4-Subsituted-9-(2-deoxy-β-D-ribosyl)-7H-pyrimido[4,5-b]indole
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An Improved Synthesis of Isonucleoside of Tubercidin
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Synthesis and Crystal Structure of 1-(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione
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An Improved Total Synthesis of 5'-Deoxytoyocamycin
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An Efficient Synthesis of 5-Bromo-4-chloro-3-indoxyl Choline Phosphate
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Reductive Transformation of p-Nitrophenol by the Effect of the Low Crystalline γ-FeOOH and Oxalic Acid
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Expression and Identification on the MPB83-MPB70 Fusion Gene of Mycobacterium bovis in Escherichia coli
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Isolation and Expression Analysis of a Putative CIPK Gene in Halophyte Sesuvium portulacastrumand L.
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 997An Improved Total Synthesis of 5'-Deoxytoyocamycin

An Improved Total Synthesis of 5'-Deoxytoyocamycin

Abstract:

In this paper, we report an efficient total synthesis of 5-deoxytoyocamycin, which was isolated from microbial sources with excellent antitumor activity. Our synthetic strategy uses 1,2,3-triacetate-5-deoxyribose as the starting material and Vorbrüggen glycosylation as the key step.

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Periodical:

Advanced Materials Research (Volume 997)

Pages:

200-202

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.997.200

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Online since:

August 2014

Authors:

Zhi Zhong Ruan, Zi Wen Gong, Qiang Xiao, Ru Chun Yang*

Keywords:

Pyrrolo[2,3-d]pyrimidine, Total Synthesis, Toyocamycin, Vorbrüggen Glycosylation

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