Effects of Immediate Stimulation on Single Nucleotide and Catecholamine Level in Chinese Tree Shrews

Abstract:

The present study examined the effects of the immediate stimuli on the levels of catecholamine and single nucleotide of Chinese tree shrew by using RIA approach. When tree shrews were under immediate stimulation, compared to the control animals, the levels of the epinephrine (E), norepinephrine (NE), adenosine monophosphate (cAMP), and cyclic guanosine phosphate (cGMP) in blood were significantly increased. Also, the acute stimulation could significantly enhance the cAMP and cGMP levels of the midbrain ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hipp), and testis (Testicle), and the dopamine (DA) levels in PFC, Hipp, striatum, and nucleus accumbens (NAc). However, when tree shrews were treated with reserpine, both the E and NE levels were significantly reduced (P < 0.01), indicating that the reserpine interventions could reduce or prevent those stress-related damages. Also, the mitochondrial index (the volume density, surface density and density) in hippocampus cells were significantly increased by 55.21%, 55.21% and 55.21% respectively (P<0.01), compared to those of the control animals housed. Our results demonstrated that the immediate stimulus can significantly affect the synthesis and release of epinephrine, norepinephrine, DA, cMAP, and cGMP in Chinese tree shrews. This study was supported by the following Chinese funding agencies: the National Natural Science Foundation of China (31060283), the National Social Science Fund (07BSH054), the Lanzhou Social Science Fund (07-1-64), and the Academic Innovation Team Building Program Management of Gansu Institute of Political Science and Law (GZF2013CXTD003).

• Periodical: Advanced Materials Research (Volumes 998-999)
• Pages: 233-237
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.998-999.233
• Online since: July 2014
• Authors: Fa Rong Yu, Xiu Zhen Lian, Ming Ren Xie*, Zuo Ping Li
• Keywords: Catecholamine Level, Chinese Tree Shrews, Forensic Pathology, Immediate Stimulus

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