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Synthesis and Self-Assembly Study of Biodegradable Amphiphilic Triblock Copolymers with PEG Block

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Abstract:

Three biodegradable amphiphilic triblock copolymers: polylactide-poly (ethylene glycol)-polylactide (PLA-PEG-PLA), poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL) and poly (lactide-glycolide)-poly (ethylene glycol)-poly (lactide-glycolide) (PLGA-PEG-PLGA) were synthesized. Their chemical structures were characterized. In aqueous solution, their self-assembly and degradation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Spherical micelles were formed in aqueous solution via self-assembly of the amphiphilic triblock copolymers. After degradation, the PLA-PEG-PLA and PCL-PEG-PCL micelles became smaller and the PLGA-PEG-PLGA micelles change to vesicles, which should mainly attribute to their different degradation speed.

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Periodical:

Advanced Materials Research (Volumes 998-999)

Pages:

95-98

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.998-999.95

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Online since:

July 2014

Authors:

Xu Du*, Qin Wang, Chuan Dong Wang, Yang Liu

Keywords:

Amphiphilic, Biodegradable, Block Copolymer, Poly(ethylene Glycol), Self-Assembly

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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