Nanotechnology-Based Cell Sheet Engineering for Regenerative Medicine

Abstract:

In order to realize true regenerative medicine, we have developed a novel technology for the reconstruction of tissues and organs by utilizing intelligent materials including temperature-responsive polymers. We developed temperature-responsive culture surfaces, on which temperature-responsive polymers are covalently immobilized. Cells are cultured on the surfaces at 37°C, and harvested as transplantable cell sheets by reducing temperature to 20°C. With these cell sheets we regenerate various kinds of tissues such as cornea and heart.

• Periodical: Advances in Science and Technology (Volume 53)
• Pages: 74-78
• DOI: https://doi.org/10.4028/www.scientific.net/AST.53.74
• Online since: October 2006
• Authors: Masayuki Yamato, Teruo Okano
• Keywords: Temperature-Responsive Surface, Tissue Engineering

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