Nanotechnology-Based Cell Sheet Engineering for Regenerative Medicine
In order to realize true regenerative medicine, we have developed a novel technology for the reconstruction of tissues and organs by utilizing intelligent materials including temperature-responsive polymers. We developed temperature-responsive culture surfaces, on which temperature-responsive polymers are covalently immobilized. Cells are cultured on the surfaces at 37°C, and harvested as transplantable cell sheets by reducing temperature to 20°C. With these cell sheets we regenerate various kinds of tissues such as cornea and heart.
P. VINCENZINI and R. BARBUCCI
M. Yamato and T. Okano, "Nanotechnology-Based Cell Sheet Engineering for Regenerative Medicine", Advances in Science and Technology, Vol. 53, pp. 74-78, 2006