Neurite Development in PC12 Cells on Nanostructured Substrates

Gui Gen Zhang; Furqan Haq; Anandan Venkatramani

doi:10.4028/www.scientific.net/AST.53.85

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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 53Neurite Development in PC12 Cells on...

Neurite Development in PC12 Cells on Nanostructured Substrates

Abstract:

We investigated the role of substrate topography on neurite development in pheochromocytoma (PC12 cells) by culturing the cells on substrates having nanoscale pillars and pores. In general, cells on nanopillars and nanopores developed fewer and shorter neurites as compared to cells on smooth substrates. But in comparison between the nanopillars the nanopores, cells on nanopores developed more and longer neurites than cells on nanopillars. These results showed that PC12 cells were spatially aware of the difference in the nanoscale structures of the underlying substrates and responded with differences in neurite outgrowth. This fact suggests the possibility to use nanoscale topographic features to control neurite development in neurons.

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Periodical:

Advances in Science and Technology (Volume 53)

Pages:

85-90

DOI:

https://doi.org/10.4028/www.scientific.net/AST.53.85

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Online since:

October 2006

Authors:

Gui Gen Zhang, Furqan Haq, Anandan Venkatramani

Keywords:

Nanopillar, Nanopore, Neurite Outgrowth, PC12 Cells, Substrate

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