Numerical Study of the Influence of the Geometric Parameters of a Radial Crystalizer Using a Multiscale CFD Model

Gustavo Villela Rodrigues; Cezar Augusto da Rosa

doi:10.4028/p-QO9GSb

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HomeDefect and Diffusion ForumDefect and Diffusion Forum Vol. 427Numerical Study of the Influence of the Geometric...

Numerical Study of the Influence of the Geometric Parameters of a Radial Crystalizer Using a Multiscale CFD Model

Abstract:

This work investigates how the configuration of the geometric parameters of a radial crystallizer influences the results of the crystallization of lovastatin by antisolvent and using a multi-scale computational fluid dynamics (CFD) model. The OPENFOAM open-source software uses macro and micromixing expressions for flow, and complete energy and population equilibrium equations during nucleation and crystal growth. The model is based on the Reynolds-Averaged-Navier-Stokes (RANS) equation, along with a multi-environment probability density function (PDF) model and the spatially semi-discretized population equilibrium equation, operating a high-resolution finite volume method. The variation crystallizer construction parameters provided another crystallizer design, and analyses demonstrated improved performance and effects on crystal distribution.

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Periodical:

Defect and Diffusion Forum (Volume 427)

Pages:

47-59

DOI:

https://doi.org/10.4028/p-QO9GSb

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Online since:

July 2023

Authors:

Gustavo Villela Rodrigues*, Cezar Augusto da Rosa

Keywords:

Antisolvent Crystallization, Computational Fluid Dynamics (CFD), Probability Density Function (PDF)

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* - Corresponding Author

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