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Preliminary Study on the Use of Hydrophobic Des-Modified SPCE Sensors for Antibiotic Detection

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Abstract:

The growing concern over antibiotic residues in the environment and food chain highlights the need for sensitive detection methods. This study reports a hydrophobic deep eutectic solvent (DES)-based modification for screen-printed carbon electrodes (SPCE) to improve antibiotic detection. The material was prepared by combining magnetic nanoparticles (MNP) with a DES of decanoic acid and 2-pentanol (1:1). This MNP-DES was applied to the SPCE surface by drop-casting. Electrochemical performance was evaluated using cyclic voltammetry (CV) from -0.1 to 0.6 V at 100 mV/s. Comparative analysis of unmodified SPCE, MNP-SPCE, and MNP-DES-SPCE showed that DES greatly enhanced the electrochemical response toward oxytetracycline (OTC) as a model antibiotic. The MNP-DES SPCE demonstrated feasibility for antibiotic detection and provides a basis for optimization to lower the detection limit to regulatory levels. This approach offers a novel strategy by exploiting the synergy of MNPs and DES, contributing to electrochemical sensor development for antibiotics.

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Periodical:

Engineering Headway (Volume 38)

Pages:

161-168

DOI:

https://doi.org/10.4028/p-bVU9dl

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Online since:

June 2026

Authors:

Chairayni Agustin, Tsana Cholidah, Iwan Cony Setiadi, Harmami Harmami, Nur Nadhirah Mohamad Zain, Abdul Wafi, Kartika A. Madurani*

Keywords:

Antibiotic, DES, Magnetic Nanoparticles, SPCE

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© 2026 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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