Heat Treatment Effect on Biological Behavior of Polyetheretherketone Composites

Abstract:

Polyetheretherketone is a semi-crystalline thermoplastic polymer, that so with heat treatments, it is possible to get different properties which are very important for the material performance. Heat treatment is a broadly utilized to develop the semi-crystalline polymers properties. In the present investigation, annealing of polyetheretherketone (PEEK) was carried out at temperatures above its glass transition temperature (Tg) to study its effects upon the biological conduct of the control and PEEK ternary composites. The bioactivity of the specimens was evaluated by investigating the apatite formation after immersion for different periods in a simulated body fluid (SBF). The biocompatibility of specimens was assessed by MTT assay. Additionally, the antibacterial property of the specimens versus S. aureus was observed with the optical density methods. The results manifested that the formation of hydroxyapatite was obviously observed on specimens after immersion for (7 and 14 days) in the simulated body fluid (SBF). Otherwise, the results of MTT assay recorded the PEEK specimens that excited the activity of fibroblasts, and therefore a high cytocompatibility was noticed and the specimens revealed antibacterial properties against S. aureus. So, the results of the bioactivity, biocompatibility and antibacterial tests in vitro demonstrated that the heat treatment enhanced biological behavior.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 54)
• Pages: 119-128
• DOI: https://doi.org/10.4028/www.scientific.net/JBBBE.54.119
• Online since: January 2022
• Authors: Alaa A. Mohammed*, Emad S. Al-Hassani
• Keywords: Antibacterial, Bioactivity, Biocompatibility, Heat Treatment, Polyetheretherketon

References

[1] M. Biron, Thermoplastics and Thermoplastic Composites, second ed., Plast. Des. Libr., William Andrew, (2013).

[2] S.M. Kurtz, J.N. Devine, PEEK biomaterials in trauma, orthopedic, and spinal implants, Biomaterials, 28 (2007) 4845-4869.

DOI: 10.1016/j.biomaterials.2007.07.013

[3] Y.Lee, R.S. Porter, Crystallization of poly(etheretherketone) (PEEK) in carbon fiber composites, Polym. Eng. Sci., 26 (1986) 633-639.

DOI: 10.1002/pen.760260909

[4] A. A. Aly, E. B. Zeidan, A. M. Hamed, W. Y. Ali, Effect of Heat Treatment On The Abrasion Resistance Of Thermoplastic Polymers, EGTRIB Journal Of The Egyptian Society of Tribology, 7(2010)52 -64.

[5] P.-Y. Jar, H. H. Kausch, W. J. Cantwell, P. Davies, H. Richard, The effect of annealing on the short and long term behavior of PEEK, Polymer Bulletin, 24 (1990)657-664.

DOI: 10.1007/bf00300163

[6] G. M. K. Ostberg, J. C. Seferis, Annealing effects on the crystallinity of polyetheretherketone (PEEK) and its carbon fiber composite, Journal of Applied Polymer Science, 33(1987)29-39.

DOI: 10.1002/app.1987.070330103

[7] A. C. Martin, N. Lakhera, A. L. DiRienzo, D. L. Safranski, A. S. Schneider, C. M. Yakacki, C. P. Frick, Amorphous-to-Crystalline Transition of Polyetheretherketone-Carbon Nanotube Composites via Resistive Heating, Composites Science and Technology, 89 (2013)110-119.

DOI: 10.1016/j.compscitech.2013.09.012

[8] M. Berer, Z. Major, G. Pinter, D.M. Constantinescu,L. Marsavina, Investigation of the dynamic mechanical behavior of polyetheretherketone (PEEK) in the high stress tensile regime, Mech Time-Depend Mater, 18 (2014)663-684.

DOI: 10.1007/s11043-013-9211-7

[9] M. Regis, A. Bellare, T. Pascolini, P. Bracco, Characterization of thermally annealed PEEK and CFR-PEEK composites: Structure-properties relationships, Polymer Degradation and Stability, 136 (2017)121-130.

DOI: 10.1016/j.polymdegradstab.2016.12.005

[10] Z. Jiang, P. Liu, H.-J. Sue, T. Bremner, Effect of annealing on the viscoelastic behavior of poly(ether-ether-ketone), Polymer, 160 (2019)231-237.

DOI: 10.1016/j.polymer.2018.11.052

[11] E. D. Avila, J. Eo, J. Kim , N. P. Kim, Heat Treatment Effect on Mechanical Properties of 3D Printed Polymers, MATEC Web of Conferences 264(2019)02001.

DOI: 10.1051/matecconf/201926402001

[12] A. A. Mohammed, E. S. Al-Hassani, J. K. Oleiwi, The Nanomechanical Characterization and Tensile Test of Polymer nanocomposites for Bioimplants, The 19th int. conference on technologies and materials for renewable energy, environment and sustainability-TMRESS, Lebanon, (2019).

DOI: 10.1063/1.5116992

[13] A. A. Mohammed, E. S. Al-Hassani, J. K. Oleiwi, S.R. Ghaffarian, The Effect of Annealing on The Behavior of Polyetheretherketone Composites Compared to Pure Titanium, Materials Research Express, 6 (2019)125405.

DOI: 10.1088/2053-1591/ab5503

[14] A. A. Mohammed, E. S. Al-Hassani, J. K. Oleiwi, Evaluation of Some Properties of Polyetheretherketone Composites Used for Biomedical Applications, 1st International Conference in Physical Science and Advance Materials, IOP Conf. Series: Materials Science and Engineering, 757 (2020) 012044.

DOI: 10.1088/1757-899x/757/1/012044

[15] T. Kokubo, H. Takadama, How useful is SBF in Predicting in Vivo Bone Bioactivity?, Biomaterials, 27 (2006) 2907-2915.

DOI: 10.1016/j.biomaterials.2006.01.017

[16] International Standard, Biological Evaluation of Medical Devices,, 3rd Edition, ISO 10993-5(2009)1-11.

[17] M. T. Khorasani, A. Joorabloo, H. Adeli, Z. Mansoori-Moghadam, A. Moghaddam, Design and Optimization of Process Parameters of Polyvinyl (alcohol)/ Chitosan/Nano Zinc Oxide Hydrogels as Wound Healing Materials, Carbohydrate Polymers, 207 (2019) 542-554).

DOI: 10.1016/j.carbpol.2018.12.021

[18] Y. Rezaei, F.Moztarzadeh, S. Shahabi, M. Tahriri, Synthesis, Characterization, and in Vitro Bioactivity of Sol-Gel-Derived SiO2-CaO-P2O5-MgO-SrO Bioactive Glass, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 44 (2014)692-701.

DOI: 10.1080/15533174.2013.783869

[19] F. E. Bastan, Fabrication and Characterization of An Electrostatically Bonded PEEK- Hydroxyapatite Composites for Biomedical Applications, Journal of Biomedical Materials Research Part B Applied.Biomaterials, 108(2020)1-15.

DOI: 10.1002/jbm.b.34583

[20] T. Yabutsuka, K. Fukushima, T. Hiruta, S. Takai, T. Yao, Effect of Pores Formation Process and Oxygen Plasma Treatment to Hydroxyapatite Formation on Bioactive PEEK Prepared by Incorporation of Precursor of Apatite, Materials Science and Engineering: C, 81 (2017)349-358.

DOI: 10.1016/j.msec.2017.07.017

[21] A. Xu, X. Liu, X. Gao, F. Deng, Y. Deng,S. Wei, Enhancement of Osteogenesis on Micro/Nano-Topographical Carbon Fiber-Reinforced Polyetheretherketone Nanohydroxyapatite Biocomposite, Materials Science and Engineering C, 48 (2015)592–598.

DOI: 10.1016/j.msec.2014.12.061