The Cell-Material Interaction in the Replacement and Regeneration of the Meniscus: A Mini-Review

Abstract:

The meniscus is a part of the knee joint consisting of a medial and lateral component between the femoral condyles and the tibial plateau. Meniscal tears usually happen in younger and active people due to sports or daily activities. Some approaches are chosen for meniscus replacement and regeneration from the problems above, such as meniscal repair, meniscal allograft transplantation, gene therapy techniques, and tissue engineering techniques. Biomaterials and tissue engineering have a primary role in meniscus regeneration and replacement. The cell-material interactions are influenced by the biomaterials' design, structure, and composition to promote the growth o meniscus tissue. This study aims to give a brief review of the cell-material interaction in the replacement and regeneration process of the meniscus. Based on several studies, the use of growth factors in the meniscal regeneration and replacement could modulate and promote angiogenesis, differentiation, and cell migration beneficial in the repair process of the meniscus. Furthermore, combining the Mesenchymal Stem Cells and growth factors in healing the meniscal tears could be one of the best approaches to obtaining the new tissue resembling the meniscal tissue. The follow-up and long-term studies in meniscus regeneration and replacement are needed and recommended, especially implanting with good chondroprotective and long-term evaluation to obtain the best properties similar to the natural meniscus.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 55)
• Pages: 56-67
• DOI: https://doi.org/10.4028/p-hfdp46
• Online since: March 2022
• Authors: Alfian Pramudita Putra*, Khairun Nisa, Dita Ayu Mayasari
• Keywords: Cell-Material Interactions, Health Care, Meniscus Regeneration, Replacement, Tissue Engineering

References

[1] E.A. Makris, P. Hadidi, and K.A. Athanasiou, The knee meniscus: Structure-function, pathophysiology, current repair techniques, and prospects for regeneration, Biomaterials, vol. 32, no. 30 (2011), p.7411–7431.

DOI: 10.1016/j.biomaterials.2011.06.037

[2] K. Vadodaria, A. Kulkarni, E. Santhini, P. Vasudevan, Materials and structures used in meniscus repair and regeneration: a review, BioMedicine, Vol. 9, No. 1(2019) pp.11-22.

DOI: 10.1051/bmdcn/2019090102

[3] M.H. Hulet, Christophe Matteo Denti, J. Espregueira-Mendes, Hélder Pereira, and Vasilios Raoulis, Surgery of the Meniscus, Surg. Meniscus (2016), p.67–78.

DOI: 10.1007/978-3-662-49188-1_7

[4] A.J S. Fox, F. Wanivenhaus, A.J. Burge, R.F. Warren, and S.A. Rodeo, The human meniscus: A review of anatomy, function, injury, and advances in treatment, Clin. Anat., vol. 28, no. 2 (2015), p.269–287.

DOI: 10.1002/ca.22456

[5] H. Li, P. Li, Z. Yang, C. Gao, L. Fu, Z. Liao, T. Zhao, F. Cao, W. Chen, Y. Peng, Z. Yuan, X. Sui, S. Liu and Q. Guo, Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications. Front. Cell Dev. Biol. 9:661802 (2021), pp.1-26.

DOI: 10.3389/fcell.2021.661802

[6] I.D. McDermott, S.D. Masouros, and A.A. Amis, Biomechanics of the menisci of the knee, Curr. Orthop., vol. 22, no. 3 (2008), p.193–201.

DOI: 10.1016/j.cuor.2008.04.005

[7] H. Kwon, W. E. Brown, C. A. Lee, D. Wang, N. Paschos, J. C. Hu, and K. A. Athanasiou, Surgical and tissue engineering strategies for articular cartilage and meniscus repair, Nat Rev Rheumatol., vol. 15, no. 9(2019), p.550–570.

DOI: 10.1038/s41584-019-0255-1

[8] S.P. Arnoczky, Building a meniscus. Biologic considerations., Clin. Orthop. Relat. Res., no. 367 Suppl (1999), p. S244-53.

[9] C. O. Kean, R. J. Brown and J. Chapman, The role of biomaterials in the treatment of meniscal tears, PeerJ (2017).

DOI: 10.7287/peerj.preprints.3111v1

[10] J.J. Rongen, T.G. van Tienen, B. van Bochove, D.W. Grijpma, and P. Buma, Biomaterials in search of a meniscus substitute, Biomaterials, vol. 35, no. 11 (2014), p.3527–3540.

DOI: 10.1016/j.biomaterials.2014.01.017

[11] G. Jacob, K. Shimomura, A. J. Krych and N. Nakamura, The Meniscus Tear: A Review of Stem Cell Therapies, Cells 2020, Vol. 9, No. 92 (2019), pp.1-17.

DOI: 10.3390/cells9010092

[12] B.L. Proffen, M. McElfresh, B.C. Fleming, and M.M. Murray, A comparative anatomical study of the human knee and six animal species, (2012).

DOI: 10.1016/j.knee.2011.07.005

[13] D. Deponti, A. Di Giancamillo, C. Scotti, G.M. Peretti, and I. Martin, Animal models for meniscus repair and regeneration, J. Tissue Eng. Regen. Med., vol. 9, no. 5 (2015), p.512–527.

DOI: 10.1002/term.1760

[14] I.D. McDermott, F. Sharifi, A.M.J. Bull, C.M. Gupte, R.W. Thomas, and A.A. Amis, An anatomical study of meniscal allograft sizing, Knee Surgery, Sport. Traumatol. Arthrosc., vol. 12, no. 2 (2004) p.130–135.

DOI: 10.1007/s00167-003-0366-7

[15] S. Arnoczky and C. Mc Devitt, The meniscus: Structure, function, repair, and replacement," Orthop. Basic Sci. (2000), p.531–545.

[16] B. Bilgen, C. T. Jayasuriya, and B. D. Owens, Current Concepts in Meniscus Tissue Engineering and Repair, Adv Healthc Mater. Vol. 7, No. 11(2018), pp.1-26.

DOI: 10.1002/adhm.201701407

[17] I.D. McDermott, S.D. Masouros, and A.A. Amis, Biomechanics of the menisci of the knee, Curr. Orthop., vol. 22, no. 3 (2008), p.193–201.

DOI: 10.1016/j.cuor.2008.04.005

[18] N. Pujol and P. Beaufils, Healing results of meniscal tears left in situ during anterior cruciate ligament reconstruction: a review of clinical studies., Knee Surg. Sports Traumatol. Arthrosc., vol. 17, no. 4 (2009), p.396–401.

DOI: 10.1007/s00167-008-0711-y

[19] P. Verdonk and P. Vererfve, Traumatic Lesions: Stable Knee, ACL Knee, in The Meniscus, P. Beaufils and R. Verdonk, Eds. Berlin, Heidelberg: Springer Berlin Heidelberg, (2010), p.45–49.

DOI: 10.1007/978-3-642-02450-4_6

[20] M. Chen, W. Guo, S. Gao, C. Hao, S. Shen, Z. Zhang, Z. Wang, Z. Wang, X. Li, X. Jing, X. Zhang, Z. Yuan, M. Wang, Y. Zhang, J. Peng, A. Wang, Y. Wang, X. Sui, S. Liu, and Q. Guo, Biochemical Stimulus-Based Strategies for Meniscus Tissue Engineering and Regeneration, BioMed Res. Intl., Vol. 2018, pp.1-15.

DOI: 10.1155/2018/8472309

[21] D.E. Kramer and L.J. Micheli, Meniscal tears and discoid meniscus in children: diagnosis and treatment., J. Am. Acad. Orthop. Surg., vol. 17, no. 11 (2009), p.698–707.

DOI: 10.5435/00124635-200911000-00004

[22] C. Laible, D.A. Stein, and D.N. Kiridly, Meniscal repair., J. Am. Acad. Orthop. Surg., vol. 21, no. 4 (2013), p.204–213.

[23] R. Verdonk et al., Indications and limits of meniscal allografts.," Injury, vol. 44 Suppl 1 (2013), p. S21-7.

[24] K.A. Milachowski, K. Weismeier, and C.J. Wirth, Homologous meniscus transplantation. Experimental and clinical results.," Int. Orthop., vol. 13, no. 1 (1989), p.1–11.

DOI: 10.1007/bf00266715

[25] M. Cucchiarini, A.L. McNulty, R.L. Mauck, L.A. Setton, F. Guilak, and H. Madry, Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus, Osteoarthritis Cartilage, Vol. 24, No. 8(2016), p.1330–1339.

DOI: 10.1016/j.joca.2016.03.018

[26] J. K. Venkatesan, A. Rey-Rico, & M. Cucchiarini, Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine, Tissue engineering and regenerative medicine, Vol. 16, No. 4(2019), p.345–355.

DOI: 10.1007/s13770-019-00179-x

[27] C. H. Evans & J. Huard, Gene therapy approaches to regenerating the musculoskeletal system. Nature reviews. Rheumatology, Vol. 11, No. 4(2015), p.234–242.

DOI: 10.1038/nrrheum.2015.28

[28] R.H. Brophy and M.J. Matava, Surgical options for meniscal replacement., J. Am. Acad. Orthop. Surg., vol. 20, no. 5 (2012), p.265–272.

[29] B.B. Mandal, S.H. Park, E.S. Gil, and D.L. Kaplan, Multilayered silk scaffolds for meniscus tissue engineering, Biomaterials, vol. 32, no. 2 (2011), p.639–651.

DOI: 10.1016/j.biomaterials.2010.08.115

[30] M. L. Tanaka , N. Vest, C. M. Ferguson & P. Gatenholm, Comparison of Biomechanical Properties of Native Menisci and Bacterial Cellulose Implant, International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 63, No. 17, (2014), pp.891-897.

DOI: 10.1080/00914037.2014.886226

[31] A. Leroy, P. Beaufils, B. Faivre, C. Steltzlen, P. Boisrenoult, and N. Pujol, Actifit® polyurethane meniscal scaffold: MRI and functional outcomes after a minimum follow-up of 5 years, Orthopaedics & Traumatology: Surgery & Research, Vol. 103, Issue 4(2017), pp.609-614.

DOI: 10.1016/j.otsr.2017.02.012

[32] C. Toanen, A. Dhollander, P. Bulgheroni, G. Filardo, S. Zaffagnini, T. Spalding, J.C. Monllau, P. Gelber, R. Verdonk, P. Beaufils, N. Pujol, E. Bulgheroni, L. Asplin, P. Verdonk, Polyurethane Meniscal Scaffold for the Treatment of Partial Meniscal Deficiency: 5-Year Follow-up Outcomes: A European Multicentric Study, Am J Sports Med, Vol. 48, No. 6(2020), pp.1347-1355.

DOI: 10.1177/0363546520913528

[33] R.T.C. Welsing et al., Effect on tissue differentiation and articular cartilage degradation of a polymer meniscus implant: A 2-year follow-up study in dogs., Am. J. Sports Med., vol. 36, no. 10 (2008), p.1978–(1989).

DOI: 10.1177/0363546508319900

[34] T. Toyonaga, N. Uezaki, and H. Chikama, Substitute meniscus of Teflon-net for the knee joint of dogs., Clin. Orthop. Relat. Res., no. 179 (1983), p.291–297.

DOI: 10.1097/00003086-198310000-00044

[35] K. Sommerlath and J. Gillquist, The effect of a meniscal prosthesis on knee biomechanics and cartilage. An experimental study in rabbits., Am. J. Sports Med., vol. 20, no. 1 (1992), p.73–81.

DOI: 10.1177/036354659202000117

[36] L. Coluccino, R. Gottardi, F. Ayadi, A. Athanassiou, R. S. Tuan, and L. Ceseracciu, Porous Poly(vinyl alcohol)-Based Hydrogel for Knee Meniscus Functional Repair, ACS Biomaterials Science & Engineering, Vol. 4, No. 5(2018), pp.1518-1527.

DOI: 10.1021/acsbiomaterials.7b00879

[37] A. Marrella, A. Lagazzo, E. Dellacasa, C. Pasquini, E. Finocchio, F. Barberis, L. Pastorino, P. Giannoni, S. Scaglione, 3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens, Polymers. Vol. 10, No. 4 (2018), p.380.

DOI: 10.3390/polym10040380

[38] J. Zellner et al., Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone, J. Biomed. Mater. Res. - Part B Appl. Biomater., vol. 101, no. 7 (2013), p.1133–1142.

DOI: 10.1002/jbm.b.32922

[39] P. Angele, R. Kujat, M. Koch and J. Zellner, Role of mesenchymal stem cells in meniscal repair, Journal of Experimental Orthopaedics, Vol. 1, No. 12(2014), pp.1-9.

DOI: 10.1186/s40634-014-0012-y

[40] U.G. Longo, M. Loppini, F. Forriol, G. Romeo, N. Maffulli, and V. Denaro, Advances in Meniscal Tissue Engineering, Stem Cells International, Volume 2012, Article ID 420346, pp.1-7.

DOI: 10.1155/2012/420346

[41] J.W. Griffin, M.M. Hadeed, B.C. Werner, D.R. Diduch, E.W. Carson, M.D. Miller. Platelet-rich plasma in meniscal repair: does augmentation improve surgical outcomes?, Clin Orthop Relat Res. Vol. 473, No. 5(2015), pp.1665-72.

DOI: 10.1007/s11999-015-4170-8

[42] M.B. Pabbruwe, W. Kafienah, J.F. Tarlton, S. Mistry, D.J. Fox, and A.P. Hollander, Repair of meniscal cartilage white zone tears using a stem cell/collagen-scaffold implant, Biomaterials, vol. 31, no. 9 (2010), p.2583–2591.

DOI: 10.1016/j.biomaterials.2009.12.023

[43] G. Jacob, K. Shimomura, A. J. Krych, and N. Nakamura, The Meniscus Tear: A Review of Stem Cell Therapies, Cells, 9, 92 (2020), pp.1-17.

DOI: 10.3390/cells9010092

[44] R. F. MacBarb, E. A. Makris, J. C. Hu, and K. A. Athanasiou, A chondroitinase-ABC and TGF-𝛽1 treatment regimen for enhancing the mechanical properties of tissue-engineered fibrocartilage,, Acta Biomaterialia, vol. 9, no. 1, p.4626–4634, (2013).

DOI: 10.1016/j.actbio.2012.09.037

[45] J. L. Puetzer, B. N. Brown, J. J. Ballyns, and L. J. Bonassar, The effect of IGF-I on anatomically shaped tissue-engineered menisci,, Tissue Engineering Part: A, vol. 19, no. 11-12, p.1443– 1450, (2013).

DOI: 10.1089/ten.tea.2012.0645

[46] Y. I. Kim, J.-S. Ryu, J. E. Yeo et al., Overexpression of TGF- 𝛽1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells,, Biochemical and Biophysical Research Communications, vol. 450, no. 4, p.1593–1599, (2014).

DOI: 10.1016/j.bbrc.2014.07.045

[47] F. Forriol, P. Ripalda, J. Duart, R. Esparza, and A. R. Gortazar, Meniscal repair possibilities using bone morphogenetic protein-7,, Injury, vol. 45, no. 4, pp. S15–S21, (2014).

DOI: 10.1016/s0020-1383(14)70005-1

[48] A. I. Bochynska, G. Hannink, R. Verhoeven, D. W. Grijpma, and P. Buma, The effect of tissue surface modification with collagenase and addition of TGF-𝛽3 on the healing potential of meniscal tears repaired with tissue glues in vitro,, Journal of Materials Science: Materials in Medicine, vol. 28, no. 1, article no. 22, (2017).

DOI: 10.1007/s10856-016-5832-0

[49] A. Abbadessa, J. Crecente-Campo, & M.J. Alonso, Engineering anisotropic meniscus: zonal functionality and spatio-temporal drug delivery. Tissue Engineering Part B: Reviews. Vol. 27, No. 2 (2021), pp.133-154.

DOI: 10.1089/ten.teb.2020.0096

[50] G.K. Tan and J.J. Cooper-White, Interactions of meniscal cells with extracellular matrix molecules: Towards the generation of tissue engineered menisci, Cell Adhes. Migr., vol. 5, no. 3 (2011), p.220–226.

DOI: 10.4161/cam.5.3.14463

[51] Moradi, L., Vasei, M., Dehghan, M. M., Majidi, M., Farzad Mohajeri, S., and Bonakdar, S. (2017). Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: in vivo study. Biomaterials 126, 18–30.

DOI: 10.1016/j.biomaterials.2017.02.022

[52] Baek, J., Lotz, M. K., and D'Lima, D. D. (2019). Core-Shell nanofibrous scaffolds for repair of meniscus tears. Tissue Eng. Part A 25, 1577–1590.

DOI: 10.1089/ten.tea.2018.0319

[53] Sun, Y., You, Y., Jiang, W., Wu, Q., Wang, B., and Dai, K. (2020). Generating ready-to-implant anisotropic menisci by 3D-bioprinting protein-releasing cellladen hydrogel-polymer composite scaffold. Appl. Mater. Today 18:100469.

DOI: 10.1016/j.apmt.2019.100469

[54] Cojocaru, D. G., Hondke, S., Kruger, J. P., Bosch, C., Croicu, C., Florescu, S., et al. (2020). Meniscus-shaped cell-free polyglycolic acid scaffold for meniscal repair in a sheep model. J. Biomed. Mater. Res. B Appl. Biomater. 108, 809–818.

DOI: 10.1002/jbm.b.34435

[55] Chae, S., Lee, S. S., Choi, Y. J., Hong, D. H., Gao, G., Wang, J. H., et al. (2021). 3D cell-printing of biocompatible and functional meniscus constructs using meniscus-derived bioink. Biomaterials 267:120466.

DOI: 10.1016/j.biomaterials.2020.120466

[56] Smyth, P.A., Green, I., Jackson, R.L., Hanson, R.R., (2014). Biomimetic Model of Articular Cartilage Based on In Vitro Experiments. Journal of Biomimetics, Biomaterials and Biomedical Engineering 21, 75–91.

DOI: 10.4028/www.scientific.net/jbbbe.21.75

[57] Puttawibul, P., Benjakul, S., Meesane, J., (2014). Freeze-Thawed Hybridized Preparation with Biomimetic Self-Assembly for a Polyvinyl Alcohol/Collagen Hydrogel Created for Meniscus Tissue Engineering. Journal of Biomimetics, Biomaterials and Biomedical Engineering 21, 17–33.

DOI: 10.4028/www.scientific.net/jbbbe.21.17

[58] Trad, Z., Barkaoui, A., & Chafra, M. (2017). A Three Dimensional Finite Element Analysis of Mechanical Stresses in the Human Knee Joint: Problem of Cartilage Destruction. Journal of Biomimetics, Biomaterials and Biomedical Engineering, 32, 29–39.

DOI: 10.4028/www.scientific.net/jbbbe.32.29

[59] Chan, A., Young, N., Tran, G. T., Miles, B., Ruys, A., & Boughton, P. (2012). A Novel Patient-Specific Regenerative Meniscal Replacement System. Journal of Biomimetics, Biomaterials and Tissue Engineering, 16, 83–95.

DOI: 10.4028/www.scientific.net/jbbte.16.83