Novel Carbidopa Functionalised Silver Nanoparticles a Selective Detection for Lead and Levodopa

Abstract:

Novel approaches to engineer nanoparticles with desired chemical characteristics open new opportunities to utilize such materials for assorted applications. In this context, various methods have been developed to prepare metal nanoparticles. In the present work, we report a single-step synthesis method to prepare silver nanoparticles by using Carbidopa which is useful in treating Parkinson's disease to increase the dopamine level of the brain. Here we used the Carbidopa drug as a capping agent. Nanoparticles were characterized by Uv-Visible spectroscopy, Particle size Analyzer (PSA), dynamic light scattering (DLS), Powder X-ray Diffractometry (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Transmission electron microscopy (TEM). Then amino acid detection study was performed with all 24 amino acids, which provides the successful data for sensing the amino acid L-dopa. These prepared nanoparticles were further applied for metal analyte studies which reveal that lead can be sensed successfully by using these nanoparticles. Nanoparticle also shows radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH).

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 59)
• Pages: 21-38
• DOI: https://doi.org/10.4028/p-5hlj88
• Online since: February 2023
• Authors: Pooja R. Popat, Kinjal Nayee, Madhya Patel, Ankit P. Patel, Ruchita J. Patel, Viral A. Patel, Bharat A. Makwana*
• Keywords: Amino Acid, Antioxidant, Carbidopa, L-Dopa, Lead Detection, Silver Nanoparticles

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