Synthesis of Biodegradable Hybrid Consisting of Hydroxyapatite and Alginate

Chikara Ohtsuki; K. Hosoya; Takahiro Kawai; Masanobu Kamitakahara; Shinichi Ogata; Toshiki Miyazaki; Masao Tanihara

doi:10.4028/www.scientific.net/KEM.284-286.779

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 284-286Synthesis of Biodegradable Hybrid Consisting of...

Synthesis of Biodegradable Hybrid Consisting of Hydroxyapatite and Alginate

Abstract:

Hybrids consisting of hydroxyapatite and biodegradable polymers are attractive materials for bone repair. We recently developed hydroxyapatite-alginate hybrids through a soaking process of alginate modified with 3-aminopropyltriethoxysilane (APES), ethylenediamine (EDA) and CaCl2 in a solution mimicking body fluid such as SBF, 1.5SBF proposed by Kokubo et al.. In this study, biological behavior of the apatite-alginate hybrid fabricated through modification with APES and CaCl2 were evaluated after implantation in a rat tibia, in comparison with that of alginate gel without hydroxyapatite. The higher degree of calcification was observed for the hydroxyapatitealginate hybrid than the alginate gel without hydroxyapatite. The hydroxyapatite precipitated on and inside alginate allowed the hybrid to show not only osteoconduction but also suitable biodegradation after implantation in bony defect.

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Periodical:

Key Engineering Materials (Volumes 284-286)

Pages:

779-782

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.284-286.779

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Online since:

April 2005

Authors:

Chikara Ohtsuki, K. Hosoya, Takahiro Kawai, Masanobu Kamitakahara, Shinichi Ogata, Toshiki Miyazaki, Masao Tanihara

Keywords:

Alginate, Biodegradable Material, Hydroxyapatite (HAP), Simulated Body Fluid (SBF)

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