Biomimetic Amphiphiles for Polymeric Micellar Carrier System

Jian Ping Xu; Jian Ji; Wei-Dong Chen; Jia Cong Shen

doi:10.4028/www.scientific.net/KEM.288-289.465

Paper Titles

Two-Dimensional Array Formation of Multi-Cellular Spheroids on Micro-Patterned Polymer Brush Surface
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Heparinized Tissue Matrices as Novel Biomaterials
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Synthesis and Antithrombogenicity Assessment of Tetramethylpyrazine-Capped Poly(Ethylene Glycol)
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Novel Prosthesis Using Silk Fibroin for Small Caliber Vascular
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Biomimetic Amphiphiles for Polymeric Micellar Carrier System
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Biodegradable Polyamides Containing Amino Acid Residues: A Chemoenzymatic Synthesis
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Preparation and Characterization of Three Dimensions Chitosan Rods with Biomimetic Layered Structure Similar to Annual Ring
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Radiation-Induced Graft Polymerization of Maleic Anhydride onto Poly-β-Hydroxybutyrate
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The Influence of Different Base Materials on Marginal Adaptation of Direct Class II Composite Resin Restorations
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Biomimetic Amphiphiles for Polymeric Micellar Carrier System

Abstract:

A commercial available amphiphilic polymer, Cholesterol terminated PEO (Chol-PEO), was used as novel biomimetic drug delivery system. The association behavior of Chol-PEOs in aqueous solution was studied by fluorescence probe technique and transmission electron microscope (TEM). Fluorescence excitation spectra for pyrene probe solubilized in the aggregates of Chol-PEOs suggested the presence of a critical micelle concentration (cmc) in water. TEM images of the aggregates suggested that the PEO block formed the biocompatible micelle coronas and the cholesterol block formed the hydrophobic micelle cores. These new biomimetic diblock copolymers were evaluated as nanocapsules for the delivery of hydrophobic drugs and drug release behavior of a hydrophobic anti-cancer drug, adriamycin (ADR), was examined.