Biodegradation of Multilayer Silk Fibroin and Hydroxyapatite Composite Material

Rikako Kino; Toshiyuki Ikoma; Shunji Yunoki; Akira Monkawa; Atsushi Matsuda; Go Kagata; Tetsuo Asakura; Masanobu Munekata; M. Tanaka

doi:10.4028/www.scientific.net/KEM.309-311.1169

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 309-311Biodegradation of Multilayer Silk Fibroin and...

Biodegradation of Multilayer Silk Fibroin and Hydroxyapatite Composite Material

Abstract:

Silk fibroin (SF) films containing 5wt% of CaCl2 were prepared by a cast-film method from the degummed SF and then immersed into the simulated body fluid (SBF) to deposit hydroxyapatite (HAp) crystals. The multilayer film of HAp and SF (5-layers), and pure SF film (4-layers) were prepared by a thermo-compression method at 130 °C and 3MPa for 4min. The ratio of β-sheet structure against other structures in both samples showed almost same value of 55.8% and 55.1%. The swelling ratio and in vitro biodegradation were examined by incubating in phosphate-buffered saline (PBS) with and without protease XIV for 1 to 14 days. The changes of sample weight and its tensile strength were investigated. The multilayer film showed slower biodegradation and higher mechanical strength compared with pure SF film.

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Periodical:

Key Engineering Materials (Volumes 309-311)

Pages:

1169-1172

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.309-311.1169

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Online since:

May 2006

Authors:

Rikako Kino, Toshiyuki Ikoma, Shunji Yunoki, Akira Monkawa, Atsushi Matsuda, Go Kagata, Tetsuo Asakura, Masanobu Munekata, M. Tanaka

Keywords:

Biodegradation, Hydroxyapatite (HAP), Multilayer, Silk Fibroin

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