The Analysis of Osteoconducting Ability of Alpha-Tricalcium Phosphate-Based Bone Filler Powder
Titanium alloy(Ti-6Al-4V, Samsung techwin, Korea) rods with diameter of 2.5mm were used as the implant materials. Polymethyl methacrylate(PMMA) bone cements(CMW, USA) were used as bone cement and -tricalcium phosphate(TCP)-based bone filler powder was used as osteoconductive additives. Hydroxyapatite(HA) was the desired end product after hydrolysis of the -TCP-based bone filler powder mixed with the blood. In animal study using rabbits, we divided the group into A, B, C and D. Rabbits were sacrificed at 1, 3, 9 weeks after implantation and the affinity index and bone density were calculated. X-ray diffraction patterns of HA formed by hydrolysis of -TCP-based bone filler powder showed higher and higher intensity in HA peak with increase of time period. There was more bone density increase in the group B and D containing - TCP-based bone filler powder around implant site than in the group A and C(p<0.05). It is suggested that HA formed by hydrolysis of -TCP-based bone filler powder will play some parts in enhancing osteconducting ability in clinical settings.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
J. H. Yoo et al., "The Analysis of Osteoconducting Ability of Alpha-Tricalcium Phosphate-Based Bone Filler Powder", Key Engineering Materials, Vols. 309-311, pp. 259-262, 2006