Bovine Serum Albumin Adsorption on Hydroxyapatite and Biphasic Calcium Phosphate and the Correlation with Zeta Potentials and Wettability
Studying on the interaction between proteins and calcium phosphate implants is one of the basic subjects in biomaterials science and engineering. In this work, zeta potentials and contact angles of hydroxyapatite (HA) and biphasic calcium phosphate (BCP) ceramics were measured, and the adsorption behaviors of bovine serum albumin (BSA) on the surfaces were investigated. The adsorption isotherms of BSA on both ceramics follow the Langmuir type, however, BCP shows higher BSA adsorption ability. The differences of contact angles and zeta potentials in HA and BCP are the key factors to determine their ability to bind BSA molecules.
Takashi Nakamura, Kimihiro Yamashita and Masashi Neo
X. D. Zhu et al., "Bovine Serum Albumin Adsorption on Hydroxyapatite and Biphasic Calcium Phosphate and the Correlation with Zeta Potentials and Wettability ", Key Engineering Materials, Vols. 309-311, pp. 73-76, 2006