Protein Adsorption Ability of Porous Hydroxyapatite Microparticle with Metal Ions

Toru Tonegawa; Toshiyuki Ikoma; Akira Monkawa; Guo Ping Chen; M. Tanaka

doi:10.4028/www.scientific.net/KEM.309-311.81

Paper Titles

Preparation and Characterization of Hydroxyapatite Microspheres with Hollow Core and Mesoporous Shell
p.65

Progress of Structural Elucidation of Amorphous Calcium Phosphate(ACP)and Hydroxyapatite (HAp): Disorder and Surfaces as Seen by Solid State NMR
p.69

Bovine Serum Albumin Adsorption on Hydroxyapatite and Biphasic Calcium Phosphate and the Correlation with Zeta Potentials and Wettability
p.73

Mesoporous Structure and Protein Adsorption Property of c-Axis Oriented Apatite Aggregates
p.77

Protein Adsorption Ability of Porous Hydroxyapatite Microparticle with Metal Ions
p.81

Effect of Mg on Surface Roughness and Protein Content of Protein-Apatite Composite Layers
p.85

Effects of Through-holes' Diameter on Initial Cell Attachment and Cell Proliferation
p.89

Stability of Cultured Osteoblasts on Calcium Phosphate Ceramics
p.93

Novel Calcium Phosphate Ceramics: The Remarkable Promoting Action on the Differentiation of the Normal Human Osteoblasts
p.97

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Protein Adsorption Ability of Porous Hydroxyapatite Microparticle with Metal Ions

Abstract:

Hydroxyapatite (HAp) also shows the high absorption ability for proteins with low degradations. In this study, to modify the absorption ability and to obtain high surface area, metal ions (Zn, Mg, Fe) were introduced in preparing the HAp nanocrystals, and porous microparticles were subsequent fabricated by a spray drying method. HAp microparticles with Zn, Mg, Fe ions had a single phase of low crystalline HAp. The specific surface area of the HAp, Mg-HAp, Fe-HAp and Zn-HAp were 87, 150, 152, 167 m2/g, respectively. In the adsorption experiment of a lysozyme as a basic proteine, Zn-HAp showed the highest adsorption ability. On the other hand, the HAp microparticles witn metal ions showed higher adsorption ability for BSA as a acitic protein than pure HAp microparticles.