Protein Adsorption Ability of Porous Hydroxyapatite Microparticle with Metal Ions

Abstract:

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Hydroxyapatite (HAp) also shows the high absorption ability for proteins with low degradations. In this study, to modify the absorption ability and to obtain high surface area, metal ions (Zn, Mg, Fe) were introduced in preparing the HAp nanocrystals, and porous microparticles were subsequent fabricated by a spray drying method. HAp microparticles with Zn, Mg, Fe ions had a single phase of low crystalline HAp. The specific surface area of the HAp, Mg-HAp, Fe-HAp and Zn-HAp were 87, 150, 152, 167 m2/g, respectively. In the adsorption experiment of a lysozyme as a basic proteine, Zn-HAp showed the highest adsorption ability. On the other hand, the HAp microparticles witn metal ions showed higher adsorption ability for BSA as a acitic protein than pure HAp microparticles.

Info:

Periodical:

Key Engineering Materials (Volumes 309-311)

Main Theme:

Edited by:

Takashi Nakamura, Kimihiro Yamashita and Masashi Neo

Pages:

81-84

DOI:

10.4028/www.scientific.net/KEM.309-311.81

Citation:

T. Tonegawa et al., "Protein Adsorption Ability of Porous Hydroxyapatite Microparticle with Metal Ions ", Key Engineering Materials, Vols. 309-311, pp. 81-84, 2006

Online since:

May 2006

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Price:

$35.00

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