Novel Calcium Phosphate Ceramics: The Remarkable Promoting Action on the Differentiation of the Normal Human Osteoblasts

Masato Tamai; Ryusuke Nakaoka; Kazuo Isama; Toshie Tsuchiya

doi:10.4028/www.scientific.net/KEM.309-311.97

Paper Titles

Protein Adsorption Ability of Porous Hydroxyapatite Microparticle with Metal Ions
p.81

Effect of Mg on Surface Roughness and Protein Content of Protein-Apatite Composite Layers
p.85

Effects of Through-holes' Diameter on Initial Cell Attachment and Cell Proliferation
p.89

Stability of Cultured Osteoblasts on Calcium Phosphate Ceramics
p.93

Novel Calcium Phosphate Ceramics: The Remarkable Promoting Action on the Differentiation of the Normal Human Osteoblasts
p.97

Sintering Effect on Mechanical Properties of Composites of Hydroxyapatite Lanthanum Oxide (HA-La₂O₃)
p.101

Osteoblast Proliferation and Morphology Analysis on Laser Modified Hydroxyapatite Surfaces: Preliminary Results
p.105

Adhesion, Proliferation and Morphology of Osteoblasts Cultured on Apatite Ceramics with Preferred Orientation to a-Plane
p.109

Rietveld Studies on Silicon Substituted Hydroxyapatite
p.113

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Novel Calcium Phosphate Ceramics: The Remarkable Promoting Action on the Differentiation of the Normal Human Osteoblasts

Abstract:

To promote the activity of normal human osteoblasts (NHOst), the novel HAp ceramics containing Nb ions (NbHAp) were synthesized by wet chemical process, which reacting aqueous solution containing a mixture of Ca(NO3)2, (NH4)2HPO4, and the Nb aqueous solution. X-ray diffraction patterns indicated that NbHAp had a monolithic apatitic structure, although crystallite decreased as Nb content increased. From inductively coupled plasma analysis, maximum amount of Nb ions in the sample was almost 8.2atom% of P ions. The NbHAps were presented as aggregates and composed of fine crystal of <1µm in diameter. Nb ions in NbHAp were uniformly distributed in the aggregates. Furthermore, high-resolution XPS spectra of Nb 3d5/2 indicated that Nb ions in the HAp were presented as Nb5+. These results suggested that Nb ions were at PO4 site in crystal structure of HAp. When NHOst were cultured with the NbHAp, their ALP activity were twice as much as that of NHOst cultured with HAp without Nb ions.