Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions
Nanocomposites consisting of biologically active ions, which can enhance cell viability and activate gene expression, are regarded as promising bone regenerative materials. We report a new method for the layer-by-layer (LbL) assembly of biologically active strontium ions in the core-shell Silica@OCP system for an efficient controlled-release. The strontium ions were assembled by using a pH-responsive electrostatic interaction to generate three-dimensional gradients within the silica nanospheres, and then a porous OCP (octacalcium phosphate) shells was coated on the microunits tailored by polyelectrolyte molecules. This core-shell-like microstructure can achieve the multicomponents administration and controlled release of essential trace silicon and zinc ions based on the barrier effect of OCP shell and pH-dependent manner, respectively.
Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu
Z. R. Gou et al., "Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions", Key Engineering Materials, Vols. 330-332, pp. 1057-1060, 2007