Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions

Abstract:

Nanocomposites consisting of biologically active ions, which can enhance cell viability and activate gene expression, are regarded as promising bone regenerative materials. We report a new method for the layer-by-layer (LbL) assembly of biologically active strontium ions in the core-shell Silica@OCP system for an efficient controlled-release. The strontium ions were assembled by using a pH-responsive electrostatic interaction to generate three-dimensional gradients within the silica nanospheres, and then a porous OCP (octacalcium phosphate) shells was coated on the microunits tailored by polyelectrolyte molecules. This core-shell-like microstructure can achieve the multicomponents administration and controlled release of essential trace silicon and zinc ions based on the barrier effect of OCP shell and pH-dependent manner, respectively.

• Periodical: Key Engineering Materials (Volumes 330-332)
• Pages: 1057-1060
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.330-332.1057
• Online since: February 2007
• Authors: Zhong Ru Gou, Wen Jian Weng, Ja Bei Zhou, Pi Yi Du, Gao Rong Han
• Keywords: Bioactive Materials, Controlled-Release, Core-Shell Structure, Trace Elements

References

[1] P. Saravanapavan, J. Selvakumaran, L.L. Hench: Key Eng Mater Vol. 254-256(2004), p.785.

[2] R.C. Bielby, I.S. Christodoulou, R.S. Pryce, et al.: Tissue Eng 10 (2004), p.1018.

[3] T. Moroashi, T. Sano, S. Yamada Jpn J Pharmaco 64 (1994), p.155.

[4] A.E. Porter, N. Patel, J.N. Skepper, et al.: Biomaterials 24(2003), p.4609.

[5] C.T. Wong, Q.Z. Chen, W.W. Lu, et al.: J Biomed Mater Res 70A(2004), p.428.

[6] A. Bigi, E. Boanini, D. Walsh, S. Mann: Angew Chem Int Ed 41(2002), p.2163.