Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions

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Nanocomposites consisting of biologically active ions, which can enhance cell viability and activate gene expression, are regarded as promising bone regenerative materials. We report a new method for the layer-by-layer (LbL) assembly of biologically active strontium ions in the core-shell Silica@OCP system for an efficient controlled-release. The strontium ions were assembled by using a pH-responsive electrostatic interaction to generate three-dimensional gradients within the silica nanospheres, and then a porous OCP (octacalcium phosphate) shells was coated on the microunits tailored by polyelectrolyte molecules. This core-shell-like microstructure can achieve the multicomponents administration and controlled release of essential trace silicon and zinc ions based on the barrier effect of OCP shell and pH-dependent manner, respectively.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

1057-1060

Citation:

Z. R. Gou et al., "Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions", Key Engineering Materials, Vols. 330-332, pp. 1057-1060, 2007

Online since:

February 2007

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$38.00

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