Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate

Abstract:

Article Preview

Osteoclasts isolated from rabbits were cultured on zinc-containing tricalcium phosphate (ZnTCP) disks with zinc contents of 0.316 and 0.633 wt%, and on β-tricalcium phosphate (TCP) disks with nearly identical porosities, grain sizes and surface roughnesses. ZnTCPs directly suppressed the resorption activity of mature osteoclasts by enhancing apoptosis. We hypothesized that resorbing osteoclasts attached to ZnTCP locally accumulate zinc ions within the space defined by the clear zone during resorption, which in turn leads to apoptosis induction, even though the change in chemical composition of the culture medium is very small.

Info:

Periodical:

Key Engineering Materials (Volumes 330-332)

Main Theme:

Edited by:

Xingdong Zhang, Xudong Li, Hongsong Fan, Xuanyong Liu

Pages:

1071-1074

DOI:

10.4028/www.scientific.net/KEM.330-332.1071

Citation:

Y. Yamada et al., "Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate", Key Engineering Materials, Vols. 330-332, pp. 1071-1074, 2007

Online since:

February 2007

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.