Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate

Yasutaka Yamada; Atsuo Ito; Hiroko Kojima; Masataka Sakane; Shumpei Miyakawa; Toshimasa Uemura; Racquel Z. LeGeros

doi:10.4028/www.scientific.net/KEM.330-332.1071

Paper Titles

Preparation of Hydroxyapatite-Alginate Gels as a Carrier for Controlled Release of Paclitaxel
p.1053

Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions
p.1057

Comparison of Osteoinduction by Autologous Bone and Biphasic Calcium Phosphate Ceramic in Goats
p.1063

Quantitative Analysis of Core Binding Factor 1 (Cbfa1) and Osteocalcin in C2C12 Cells Induced by Ca/P Ceramics In Vitro
p.1067

Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate
p.1071

Titanium-Reinforced Polytetrafluoroethylene Membrane Combined with Inorganic Polyphosphate Induces Exophytic Bone Formation in Rabbit Calvaria
p.1075

Development of EGFP-Expressing Cell Line for Biocompatibility Evaluation of Osteoinductive CaP Ceramics
p.1079

Effect Of HA/TCP Biphasic Ceramic on Osteoinduction
p.1083

Gene Expression Profile of Osteoblast-Like Cells on Calcium Phosphate Biomaterials
p.1087

HomeKey Engineering MaterialsKey Engineering Materials Vols. 330-332Attenuation of Osteoclastic Activity Induced by...

Attenuation of Osteoclastic Activity Induced by Zinc-Containing Tricalcium Phosphate

Abstract:

Osteoclasts isolated from rabbits were cultured on zinc-containing tricalcium phosphate (ZnTCP) disks with zinc contents of 0.316 and 0.633 wt%, and on β-tricalcium phosphate (TCP) disks with nearly identical porosities, grain sizes and surface roughnesses. ZnTCPs directly suppressed the resorption activity of mature osteoclasts by enhancing apoptosis. We hypothesized that resorbing osteoclasts attached to ZnTCP locally accumulate zinc ions within the space defined by the clear zone during resorption, which in turn leads to apoptosis induction, even though the change in chemical composition of the culture medium is very small.