Biomimetic Fabrication and Characterization of BG/COL/HCA Scaffolds for Bone Tissue Engineering

Xiao Feng Chen; Ying Jun Wang; Chun Rong Yang; Na Ru Zhao

doi:10.4028/www.scientific.net/KEM.336-338.1574

Paper Titles

The Interface Reaction between an Ag⁺-Doped TiO₂ Film and Stainless Steel Substrate
p.1559

Preparation of Antibacterial Ceramics with Silver-Carrying Nano-Hydroxyapatite
p.1563

Effect of Reaction Conditions on Pore Configuration and Mechanical Property for Porous Hydroxyapatite Prepared by Polymer Sponge Method
p.1567

Factors Affecting the Pore Size in Porous Hydroxyapatite Produced by Stir-Froth-Polymerization Method
p.1571

Biomimetic Fabrication and Characterization of BG/COL/HCA Scaffolds for Bone Tissue Engineering
p.1574

FCVA-Synthesized Tetrahedral Amorphous Carbon Films for Biomedical Applications
p.1577

A Study on Biomineralization Behavior of Silk Fibroin Film
p.1581

MicroCT Aided Scaffold Design and Preparation
p.1584

Mechanical Properties of Machinable Zirconia Dental Composites
p.1587

HomeKey Engineering MaterialsKey Engineering Materials Vols. 336-338Biomimetic Fabrication and Characterization of...

Biomimetic Fabrication and Characterization of BG/COL/HCA Scaffolds for Bone Tissue Engineering

Abstract:

The bone tissue engineering scaffold was developed by compounded the type I collagen with the porous scaffold of the sol-gel derived bioactive glass (BG) in the system CaO-P2O5-SiO2. The resultant porous scaffold was treated in supersaturated calcification solution (SCS) to form the surface layer of hydroxyl-carbonate-apatite (HCA) since the type I collagen possessed good biocompatibility and bio-absorbability, and also, the ability of inducting calcium phosphates to precipitated inside and outside the collagen fibers where the collagen fibers acted as bio-macromolecules template for formation of bone-like inorganic minerals in nature bone such as: octo-calcium phosphate (OCP), tri-calcium phosphate (TCP) and hydroxyl-carbonate-apatite (HCA). On the other hand, the sol-gel derived bioactive glass also played an important role in formation of the above bio-minerals owing to its serial chemical reactions with the body fluid. The in vitro study in supersaturated calcification solution SCS indicated that the surface of the porous scaffold was able to induce formation of bone-like HCA crystals on the pore walls of the scaffold which possessed satisfactory cells biocompatibility.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 336-338)

Pages:

1574-1576

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.336-338.1574

Citation:

Cite this paper

Online since:

April 2007

Authors:

Xiao Feng Chen, Ying Jun Wang, Chun Rong Yang, Na Ru Zhao

Keywords:

Bioactive Glass, Bio-Mimetic Synthesis, Collagen, Tissue Engineering Scaffold

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] C.M. Agrawal and R.B. Ray: J. Biomed. Mater. Res. Vol55 (2001), p.141.

Google Scholar

[2] M.C. Chang, T. Ikoma, M. Kikuchi and J. Tanaka: J. Mater. Sci. Mat. Med. Vol13 (2002), p.993.

Google Scholar

[3] C.R. Lee, A.J. Grodzinsky and M. Specto: Biomaterials Vol22 (2001), p.3145.

Google Scholar

[4] C.L. Tsai, S.H. Hsu and W.L. Cheng: Artif. Organs Vol26 (2002), p.18.

Google Scholar

[5] S.I. Stupp and P.V. Braun: Science Vol277 (1997), p.1242.

Google Scholar

[6] M.C. Chang, T. Ikoma, M. Kikuchi and J. Tanaka: J. Mater. Sci. Lett. Vol20 (2001), p.199.

Google Scholar

[7] M. Kikuchi, S. Itoh, S. Ichinose and J. Tanaka: Biomaterials Vol22 (2001), p.1705.

Google Scholar

[8] P. Angele, J. Abke, R. Kujat, H. Faltermeier, D. Schumann, M. Nerlich, B. Kinner, C. Englert, Z. Ruszczak, R. Mehrl and R. Mueller: Biomaterials Vol25 (2004), p.2831.

DOI: 10.1016/j.biomaterials.2003.09.066

Google Scholar

[9] X. Su, K. Sun, F. Z. Cui and W. J. Landis: Bone Vol32 (2003), p.150.

Google Scholar