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Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent

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Abstract:

In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid (NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore, LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated endocytosis.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

469-472

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.469

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Online since:

July 2007

Authors:

Dong Gon Kim, Min Ja Jang, Chang Yong Choi, Tae Hyeong Kim, Mi Kyeong Jang, Jae Woon Nah

Keywords:

Endocytosis, LMWSC, Paclitaxel, Receptor, Tumor Targeting

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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