Novel Poly(Ester Amine) Based on Polycaprolactone and Polyethylenimine as a Gene Carrier: Effect of Hydrophobicity on Transfection Efficiency and Cytotoxicity

Rohidas B. Arote; Tae Hee Kim; You Kyoung Kim; Dhananjay Jere; Hu Lin Jiang; In Young Park; Myung Haing Cho; Jae Woon Nah; Chong Su Cho

doi:10.4028/www.scientific.net/KEM.342-343.453

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 342-343Novel Poly(Ester Amine) Based on Polycaprolactone...

Novel Poly(Ester Amine) Based on Polycaprolactone and Polyethylenimine as a Gene Carrier: Effect of Hydrophobicity on Transfection Efficiency and Cytotoxicity

Abstract:

Novel, biodegradable poly(ester amine)s (PEAs) were synthesized using hydrophobic polycaprolactone diacrylate (PCLDA) and highly cationic polyethylenimine (PEI). This novel gene carrier can form stable DNA complexes with particle sizes around 200 nm, and showing excellent transfection efficiency and relatively low cytotoxicity compared with PEI 25K. Effect of hydrophobicity on transfection efficiency and cytotoxicity was profound and was relatively important parameter for the success of gene delivery.

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Key Engineering Materials (Volumes 342-343)

Pages:

453-456

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.453

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Online since:

July 2007

Authors:

Rohidas B. Arote, Tae Hee Kim, You Kyoung Kim, Dhananjay Jere, Hu Lin Jiang, In Young Park, Myung Haing Cho, Jae Woon Nah, Chong Su Cho

Keywords:

Gene Delivery, Hydrophobicity, Poly(ester amine), Polycaprolactone, Polyethyleneimine

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