Comparison of HAp and β-TCP in BMP-2 Dose-Response and Release Study

Junichi Tazaki; Toshiyuki Akazawa; Masaru Murata; Masaya Yamamoto; Yasuhiko Tabata; J. Hino; Makoto Arisue; Takanori Shibata

doi:10.4028/www.scientific.net/KEM.361-363.1033

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 361-363Comparison of HAp and β-TCP in BMP-2 Dose-Response...

Comparison of HAp and β-TCP in BMP-2 Dose-Response and Release Study

Abstract:

The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I–labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.

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Key Engineering Materials (Volumes 361-363)

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1033-1036

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1033

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Online since:

November 2007

Authors:

Junichi Tazaki, Toshiyuki Akazawa, Masaru Murata, Masaya Yamamoto, Yasuhiko Tabata, J. Hino, Makoto Arisue, Takanori Shibata

Keywords:

BMP-2, Dose-Response, HAp, Release, β-Tricalcium Phosphate (β-TCP)

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