Comparison of HAp and β-TCP in BMP-2 Dose-Response and Release Study
The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I–labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.
Guy Daculsi and Pierre Layrolle
J. Tazaki et al., "Comparison of HAp and β-TCP in BMP-2 Dose-Response and Release Study", Key Engineering Materials, Vols. 361-363, pp. 1033-1036, 2008