Comparison of the Biological Behavior of Wollastonite Bioceramics Prepared from Synthetic and Natural Precursors
Wollastonite bioceramics prepared from synthetic and natural precursors were implanted in rats in bone and subcutaneous tissues. The implant sites were excised after 7, 30 and 120 days, fixed, dehydrated, embedded in paraffin wax for serial cutting and examined under transmitted light microscope. It was found a very similar behavior for both wollastonite bioceramics. They were biocompatible, bioactive and biodegradable when implanted in rat bone. The synthetic ceramic was more reabsorbable than the one from natural powder. When implanted in subcutaneous rat tissue, both materials elicited a mild initial inflammatory reaction that practically disappeared after 120 days. Both materials were encapsulated with a very thin fibrous capsule and slightly reabsorbed at their surfaces. None of the materials induced ectopic osteogenesis. According to the results, the studied materials seem to be able for manufacturing reabsorbable bone implants.
Guy Daculsi and Pierre Layrolle
A. M. Minarelli Gaspar et al., "Comparison of the Biological Behavior of Wollastonite Bioceramics Prepared from Synthetic and Natural Precursors", Key Engineering Materials, Vols. 361-363, pp. 1083-1086, 2008