Enhancement of the Mechanical Property of Apatite-Fiber Scaffold Using Type I-Collagen

Abstract:

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We have successfully fabricated apatite-fiber scaffolds (AFSs) that enable three-dimensional cell culture. The AFSs possessing large pores of 100~250 μm and micro pores of about 5 μm were fabricated by firing the green compacts consisting of the single-crystal apatite fibers and the carbon beads with a size of 150 μm. In order to enhance the mechanical properties of the AFSs, we have improved the process of AFS fabrication: Collagen gel (type I) solutions were introduced into the pores in the scaffolds; in addition, the resulting apatite/collagen scaffolds were chemically modified by thermally dehydrated cross-linking. Actually, the results of compressive strength tests show that the value of the AFS with chemically cross-linked I-collagen was about twice as high as that of the conventional AFS without I-collagen. We conclude that combination of I-collagen and thermal dehydrated cross-linking is effective for enhancement of the mechanical properties of AFSs.

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Main Theme:

Edited by:

Guy Daculsi and Pierre Layrolle

Pages:

943-946

DOI:

10.4028/www.scientific.net/KEM.361-363.943

Citation:

S. Motojima et al., "Enhancement of the Mechanical Property of Apatite-Fiber Scaffold Using Type I-Collagen", Key Engineering Materials, Vols. 361-363, pp. 943-946, 2008

Online since:

November 2007

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Price:

$35.00

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