New Injectable Bone Substitute Using Reversible Thermosensitive Hydrogel and BCP Granules: In Vivo Rabbit Experiments
We have developed a new injectable bone substitute combining specific granules of BCP with or without radiopaque elements with a reversible thermo sensitive resorbable carrier such as Pluronic F-127. The composite is liquid at ambient temperature and set as hydrogel at 37°C. Rabbit experiment demonstrates high biocompatibility and bone ingrowth at the expense of the injectable bioceramic composite.
Marcelo Prado and Cecília Zavaglia
G. Daculsi et al., "New Injectable Bone Substitute Using Reversible Thermosensitive Hydrogel and BCP Granules: In Vivo Rabbit Experiments", Key Engineering Materials, Vols. 396-398, pp. 457-460, 2009