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PLGA-Hydroxyapatite Composite Scaffolds for Osteoblastic-Like Cells

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Abstract:

The aim of this work was to investigate the behaviour of rat calvarial osteoblastics cells on porous PLGA/HA composite scaffolds. Cells were submitted to cytotoxicity and cell adhesion assay. In addition, the cells morphology were observed by SEM, and the collagen synthesis measured by Sirius Red colorimetric method. The results showed that the material was not cytotoxic and hydroxyapatite improved cell adhesion. Osteoblastic cells could adhere and spread on the scaffolds as observed. After 14 days the presence of hydroxyapatite increased the synthesis of collagen. This study demonstrates that composite scaffolds presented better cellular responses compared to polymer scaffolds.

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Periodical:

Key Engineering Materials (Volumes 396-398)

Pages:

461-464

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.461

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Online since:

October 2008

Authors:

André Dutra Messias, Aguedo Aragones, Eliana Aparecida de Rezende Duek

Keywords:

Bone Tissue Engineering, Cell Adhesion, Collagen Synthesis, Hydroxyapatite (HAP), Osteoblast, PLGA, Poly(L-Lactic-Co-Glycolic Acid)

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© 2009 Trans Tech Publications Ltd. All Rights Reserved

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