PLGA-Hydroxyapatite Composite Scaffolds for Osteoblastic-Like Cells

Abstract:

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The aim of this work was to investigate the behaviour of rat calvarial osteoblastics cells on porous PLGA/HA composite scaffolds. Cells were submitted to cytotoxicity and cell adhesion assay. In addition, the cells morphology were observed by SEM, and the collagen synthesis measured by Sirius Red colorimetric method. The results showed that the material was not cytotoxic and hydroxyapatite improved cell adhesion. Osteoblastic cells could adhere and spread on the scaffolds as observed. After 14 days the presence of hydroxyapatite increased the synthesis of collagen. This study demonstrates that composite scaffolds presented better cellular responses compared to polymer scaffolds.

Info:

Periodical:

Key Engineering Materials (Volumes 396-398)

Main Theme:

Edited by:

Marcelo Prado and Cecília Zavaglia

Pages:

461-464

DOI:

10.4028/www.scientific.net/KEM.396-398.461

Citation:

A. Dutra Messias et al., "PLGA-Hydroxyapatite Composite Scaffolds for Osteoblastic-Like Cells", Key Engineering Materials, Vols. 396-398, pp. 461-464, 2009

Online since:

October 2008

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Price:

$35.00

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