Biological Safety Assessment of a Colored Zirconia Ceramic: Cell Toxicity and Skin Sensitivity Tests

Abstract:

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Objective: To evaluate the biological safety of a colored zirconia ceramic in terms of cellular toxicity and a skin sensitivity test. Methods: the cytotoxicity of the ceramic was evaluated by a molecular filtration method and skin irritation activity of the composite was assessed via intradermal injection of a guinea pig test solution, by inducing, enhancing, and stimulating an allergic response after local tissue exposure. Results: cell-coated filter paper in contact with test material showed the appearance of intracellular blue dye at the same staining density as in control samples, leading to a 0 toxicity rating. Guinea pigs showed no obvious erythema or edema from the irritation test, such that the assessment of colored zirconia ceramic skin allergy response in guinea pig was 0%. Conclusion: this colored zirconia ceramic showed low cytotoxicity and elicited no allergic skin inflammation response, indicating good overall biological safety under these conditions.

Info:

Periodical:

Edited by:

Yiwang Bao, Danyu Jiang, Li Tian and Jianghong Gong

Pages:

509-512

DOI:

10.4028/www.scientific.net/KEM.492.509

Citation:

H. X. Lu et al., "Biological Safety Assessment of a Colored Zirconia Ceramic: Cell Toxicity and Skin Sensitivity Tests", Key Engineering Materials, Vol. 492, pp. 509-512, 2012

Online since:

September 2011

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Price:

$35.00

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