Biological Safety Assessment of a Colored Zirconia Ceramic: Cell Toxicity and Skin Sensitivity Tests

Abstract:

Objective: To evaluate the biological safety of a colored zirconia ceramic in terms of cellular toxicity and a skin sensitivity test. Methods: the cytotoxicity of the ceramic was evaluated by a molecular filtration method and skin irritation activity of the composite was assessed via intradermal injection of a guinea pig test solution, by inducing, enhancing, and stimulating an allergic response after local tissue exposure. Results: cell-coated filter paper in contact with test material showed the appearance of intracellular blue dye at the same staining density as in control samples, leading to a 0 toxicity rating. Guinea pigs showed no obvious erythema or edema from the irritation test, such that the assessment of colored zirconia ceramic skin allergy response in guinea pig was 0%. Conclusion: this colored zirconia ceramic showed low cytotoxicity and elicited no allergic skin inflammation response, indicating good overall biological safety under these conditions.

• Periodical: Key Engineering Materials (Volume 492)
• Pages: 509-512
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.492.509
• Online since: September 2011
• Authors: Huai Xiu Lu, Bin Deng, Long Quan Shao, Yuan Fu Yi, Jie Liu, Wei Wei Zhang, Ning Wen
• Keywords: Biomedical Application, Cell Toxicity Test, Colored Zirconia Ceramic, Skin Sensitivity Test, Zro₂

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