Minocycline Modification of Gelatin-Hydroxylapatite Composite by Co-Precipitation Method

Abstract:

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Minocycline, a semi-synthetic tetracycline antibiotic, was incorporated into gelatin- hydroxyapatite (HA) composite by using a biomimetic co-precipitation method, Firstly, a certain amount of acidic solution of hydroxyapatite was added into gelatin solution dropwise. After that, different amounts of minocycline (0mg, 50mg, 100mg, 200mg, 300mg) solution was added into the reaction system respectively , and obtain the hydroxyapatite - gelatin- minocycline composite. The results showed that the amount of the minocycline impacted the structure of the composite, and minocycline affects HA crystal growth by maybe bonding to 300 face. The approach described here may provide a basis for the preparation of an antibacterial biomaterial for bone regeneration.

Info:

Periodical:

Edited by:

Yiwang Bao, Danyu Jiang, Li Tian and Jianghong Gong

Pages:

513-516

DOI:

10.4028/www.scientific.net/KEM.492.513

Citation:

X. P. Zhu et al., "Minocycline Modification of Gelatin-Hydroxylapatite Composite by Co-Precipitation Method", Key Engineering Materials, Vol. 492, pp. 513-516, 2012

Online since:

September 2011

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Price:

$35.00

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