Gradient Organic Inorganic Nanocomposites for Tissue Repair at the Cartilage/Bone Interface

Abstract:

Article Preview

Damages to articular cartilage that are caused by trauma, age-related diseases (arthritis, arthrosis) and/or physical stress pose major medical problems. A possible solution is to introduce a biodegradable sponge-like scaffold containing cartilage-forming cells. In the current work we developed a model for a partially calcified functional biomedical membrane with a gradient of calcium phosphate crystal density to form the interface between bone and a sponge-like cell containing scaffold for cartilage regeneration. The membrane consists of a biocompatible, biodegradable, partially calcified hydrogel, in our case gelatin was used. One part is an organic-inorganic nanocomposite consisting of nanocrystalline calcium phosphate particles, formed in situ within the hydrogel, while the other part is the hydrogel without inorganic crystals. The experimental method used was one-dimensional single diffusion. Gelatin gels containing calcium or phosphate ions, respectively, were exposed from the upper side to a solution of the other constituent ion (i.e. a sodium phosphate solution was allowed to diffuse into a calcium containing gel and vice versa). Scanning electron microscopy (E-SEM), EDX, XRD and ATR-FTIR spectroscopy confirmed the existence within the gel of a density gradient of carbonate apatite crystals, with a dense top layer extending several microns into the gel. Ca/P atomic ratios were in the range characteristic of calcium deficient apatites. The effect of different experimental parameters on the calcification process within the gelatin membranes is discussed.

Info:

Periodical:

Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin

Pages:

577-581

DOI:

10.4028/www.scientific.net/KEM.493-494.577

Citation:

M. G. Aviv et al., "Gradient Organic Inorganic Nanocomposites for Tissue Repair at the Cartilage/Bone Interface", Key Engineering Materials, Vols. 493-494, pp. 577-581, 2012

Online since:

October 2011

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.