Fabrication of Organic/Inorganic Hybrids by Infiltration of Commercially-Available PLGA into Porous Hydroxyapatite Ceramics and its Material Properties
Hybrids of hydroxyapatite (HAp) and poly(L-lactic co glycolic) (PLGA) have been fabricated, which can be expected to be a novel ﬁller for bone grafting. The porous HAp ceramics with bimodal pore structure have been fabricated from apatite fibers synthesized by homogeneous precipitation method. Then, HAp/PLGA hybrids have been fabricated by introducing PLGA having high molecular-weight into the open pores of the porous HAp ceramics. Total porosities of the porous HAp ceramics slightly decreased from 71.5% down to 67.4% after infiltrating PLGA into the porous HAp ceramics. The bending strength of the HAp/PLGA hybrids was ~ 8.3 MPa. The value attained about 2 times that of the porous HAp ceramics.
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
N. Osada et al., "Fabrication of Organic/Inorganic Hybrids by Infiltration of Commercially-Available PLGA into Porous Hydroxyapatite Ceramics and its Material Properties", Key Engineering Materials, Vols. 493-494, pp. 556-560, 2012