Silicate and Calcium Ions Releasing Biomaterials for Bone Reconstruction

Abstract:

Siloxane-containing vaterite (SiV) / poly (lactic acid) hybrid (SiPVH) beads with the releasability of silicate and calcium ions were prepared with an electrospraying method. According to the increase in the silicon content of the SiV, the amount of silicate ion released from the resulting beads also increased. When the beads were soaked in a cell culture medium, proteins derived from fetal bovine serum were adsorbed on their surfaces. Cell adhesion tests were also performed on the beads with using mouse osteoblast-like cell line (MC3T3-E1) in vitro. After 5 days of culturing, the cells adhered and spread well to cover the surface of the beads. In the localized area, agglomerated cells were observed to combine with cauliflower-shaped calcium phosphate deposits.

• Periodical: Key Engineering Materials (Volumes 493-494)
• Pages: 561-565
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.493-494.561
• Online since: October 2011
• Authors: Jin Nakamura, Akiko Obata, Julian R. Jones, Toshihiro Kasuga
• Keywords: Calcium Carbonate, Ion-Release, Siloxane

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