Effect of Silver Concentration on Bioactivity and Antibacterial Properties of SiO2-CaO-P2O5 Sol-Gel Derived Bioactive Glass
Human beings are often infected by microorganisms in the living environment. Among various natural and inorganic substances, silver or silver ions have a powerful antibacterial activity. In the present study, the bioactivity and antibacterial activity of the SiO2–CaO–P2O5–Ag2O was compared with that of its ternary counterpart glass system (as a control sample) in vitro. The molar ratio of silver oxide in the bioactive glass composition was considered as different amount (0.5%, 1% and 2%). The surface characterization was evaluated after soaking in simulated body fluid (SBF). The sharpest apatite peak in X-ray diffraction (XRD) analyse after 7 days soaking in SBF was observed for 2% Ag sample (2%Ag-BG). Hence, the antibacterial effects of 2%Ag-BG sample against 2 gram negatives bacterium were examined by agar plate test. The result showed that the amount of silver did not prevent the HAp formation. Also, the antibacterial properties of 2%Ag-BG sample indicated near 100% bactericidal ratio (according to the width of antibacterial halo).
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
N. Nezafati et al., "Effect of Silver Concentration on Bioactivity and Antibacterial Properties of SiO2-CaO-P2O5 Sol-Gel Derived Bioactive Glass", Key Engineering Materials, Vols. 493-494, pp. 74-79, 2012